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Tag: NMR

April 24, 2024 CD as API / Drug delivery / Pharma applications

Characterization of the substitution pattern of 2-hydroxypropyl-β-cyclodextrin using NMR spectroscopy

2-Hydroxypropyl-β-cyclodextrin (HPBCD) is one of the most important cyclodextrin derivatives, finding extensive applications in the pharmaceutical sector. Beyond its role

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April 20, 2022 CD derivatives / Drug delivery / Pharma applications

Dramatically Increased Binding Constant of Water-Soluble Cyclodextrin Hyperbranched Polymers

The polymerization of cyclodextrin (CD) with epichlorohydrin (ECH) dramatically increases the binding constant of CD to vanillin, from 55 to

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April 12, 2022 Drug delivery / Pharma applications

Sulfobutylation of Beta-Cyclodextrin Enhances the Complex Formation with Mitragynine: An NMR and Chiroptical Study

Mitragynine (MTR), the main indole alkaloid of the well-known plant kratom (Mitragyna speciosa) is a partial agonist on the opioid

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April 6, 2022 CD derivatives

Cyclodextrin-Oligocaprolactone Derivatives-Synthesis and Advanced Structural Characterization by MALDI Mass Spectrometry

The β-cyclodextrin derivatization with short oligoester chains, through convenient synthesis methods, leads to highly water-soluble and biodegradable compounds. Cyclodextrins have

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December 2, 2021 Uncategorized

Molecular interactions in remdesivir-cyclodextrin systems

In a recently published study intermolecular interactions of remdesivir and various cyclodextrin derivatives were characterized by extensive NMR spectroscopy. The

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August 30, 2021 Drug delivery / Pharma applications

Doxorubicin-Loaded Metal-Organic Frameworks Nanoparticles with Engineered Cyclodextrin Coatings

Recently developed, nanoscale metal-organic frameworks (nanoMOFs) functionalized with versatile coatings are drawing special attention in the nanomedicine field. Core–shell MIL-100(Al)

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November 3, 2020 E-ducation

Chapter 3: Professor Casu and Cyclodextrins

Chapter 3 in the recently published book on the history of cyclodextrin is on Professor Benito Casu (1927-2016), who was

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May 8, 2020 CD derivatives / Drug delivery / Pharma applications

Chlorpromazine complexation with Sugammadex – an extremely high complexation constant

An in press paper on detailed ITC and NMR study of chlorpromazin complexation with various cyclodextrins reports on an unexpected

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December 11, 2018 E-ducation

Symmetrical conformers of naturally occurring cyclodextrins

Due to the high flexibility of the glucose units CDs can be described by many conformers. Recent advances in high-performance

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Recent Posts

  • HPβCD’s Promise in Treating Ischemic Stroke
  • Surface-Engineered Amino-Graphene Oxide Aerogel Functionalized with Cyclodextrin for Desulfurization and Denitrogenation in Oil Refining
  • Cyclodextrin and KR12-Lipopeptide Interactions
  • Comparative study of thiolated and alkenylated functionalized β-CDs as highly mucopenetrating and mucoadhesive drug delivery systems.
  • Phosphorylated Beta-cyclodextrin as a New Bone-Targeting Drug Delivery System Could Change the Treatment of Osteoporosis and Other Bone Diseases

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Top Posts

  • HPβCD's Promise in Treating Ischemic Stroke
  • Oculis: eye drops with Dexamethasone/gamma-CD complex Phase 3 study concluded soon
  • Lanosterol eye drops for cataract treatment
  • Flame-Resistant 3D Printing with Cyclodextrin: A Hewlett-Packard Patent Application
  • Sun-protective clothing using benzophenone/CD complex
  • Arthur Lütringhaus, Godfather of catenanes was born 120 years ago
  • Phosphorylated Beta-cyclodextrin as a New Bone-Targeting Drug Delivery System Could Change the Treatment of Osteoporosis and Other Bone Diseases
  • Surface-Engineered Amino-Graphene Oxide Aerogel Functionalized with Cyclodextrin for Desulfurization and Denitrogenation in Oil Refining
  • Minimizing tissue reactions with cyclodextrins at infusion site of insulin therapy
  • Does Vinblastine Retain its Anticancer Effect in the Presence of Cyclodextrin? A Preliminary Study

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