Ozonized HPBCDs as novel materials with oxidative and bactericidal properties
Ozonized (2-Hydroxypropyl)-β-cyclodextrins (Oz-HPbCDs) were produced by direct gas/solid reaction between gaseous ozone (O3) and solid HPbCD. The solid materials obtained
Tag: HPBCD
Safety, Immunogenicity of a Novel HPBCD-Adjuvanted Influenza Vaccine
A novel quadrivalent seasonal influenza vaccine (FluCyd-vac) adjuvanted with hydroxypropropyl-b-cyclodextrin (HP-β-CD) was found to be safe and immunogenic despite containing
Chewable formulations – recent reviews
Since their introduction, chewable dosage forms have gained traction due to their ability to facilitate swallowing, especially in paediatric, geriatric
The Effect of Cyclodextrins in Cholesterol and Ganglioside Depletion in Rat Brain Synaptosomes
In this recently published article, the effect of four cyclodextrin derivatives on cholesterol and ganglioside depletion was investigated: two alpha
Cyclodextrin-based delivery systems in parenteral formulations: A critical update review
Amongst all the strategies that can be useful in the development of parenteral formulations, the formation of water-soluble host-guest inclusion
Hot-melt extrusion for cyclodextrin inclusion complex of a multicomponent natural product
This study aimed to investigate whether hot-melt extrusion (HME) processing can promote molecular encapsulation of a multi-component natural product composed
Ensemble Simulations of 2-Hydroxypropyl-β-cyclodextrin Complexes with All-Atom Molecular Dynamics Simulations
2-Hydroxypropyl-β-cyclodextrins (HP-β-CDs) ability to form inclusion complexes with lipophilic compounds is important both to treat Niemann Pick Type C disease
HPaCD against Alzheimer Disease
HP-beta-cyclodextrin (HPbCD) is currently in clinical trials against Niemann-Pick Disease Type C (NPC) and Alzheimer’s Disease (AD) and these trials
Cellular Effects of Cyclodextrins: Studies on Caco-2 and HeLa Cells
In this work the cellular internalization and the intracellular effects of (2-hydroxypropyl)-beta (HPBCD) and random methyl-beta cyclodextrin (RAMEB) on Caco-2
Ultrasound-Responsive Cyclodextrin Delivery as Therapy for Atherosclerosis
Atherosclerosis is a major cause of mortality and morbidity worldwide. Left undiagnosed and untreated, atherosclerotic plaques can rupture and cause