Posted by Since their introduction, chewable dosage forms have gained traction due to their ability to facilitate swallowing, especially in paediatric, geriatric and dysphagia patients. Their benefits stretch beyond human use to also include veterinary applications, improving administration and palatability in different animal species. [1] It can be taken without water and used for improved patient compliance, suitable to be administered to patients with swallowing difficulties, especially to children and geriatric patients. It can be utilized for drug administration locally, such as fluoride-containing gum for dental carries prophylaxes or systemically such as silver acetate and nicotine gum for smoking cessation.[2]
Recently 3 reviews have been published on chewing formulations [1-3]. CD is not mentioned in [1] and [2], but dextrin as a carrier in [3]. In the CycloLab’s list of marketed drugs there are 4 active ingredients in CD enabled chewing formulations:
| Drug | CD | Trade Name | Dosage form | Company |
| Acetaminophen | BCD/ HPBCD | Acetaminophen Chewable Gels/ Paracetamol | Tablet, chewable | 7T Pharma, USA |
| Cetirizine | BCD | Zyrtec/WalZyr/Revicet | Chewing tablet/OD tablet/dry syrup | Losan Pharma/ UCB Pharma, Sandoz, Walgreen |
| Diphenhydramine | BCD/ HPBCD | Stada-Travel/ FirstCare – Children’s Allergy Relief | Chewing tablet | Stada/ FirstCare |
| Nicotine | BCD | Nicorex/ Nicorette | Tablet | Pierre Fabre |
| Nicogum | Chewing gum | Pfizer |
References:
[1] Rodríguez-Pombo, L.; Awad, A.; Basit, A.W.; Alvarez-Lorenzo, C.; Goyanes, A. Innovations in Chewable Formulations: The Novelty and Applications of 3D Printing in Drug Product Design. Pharmaceutics 2022, 14, 1732. https://doi.org/10.3390/pharmaceutics14081732
[2] Zainab A. Sade, Mais F. Mohamme, Najwan K. Fakree, Medicated Chewing Gum: A Review. IJDDT 2022, 12, 428-431
[3] Morteza Banakar, Sedigheh Moayedi, Erfan Shamsoddin, Zahra Vahedi, Mohammad Hasan Banakar, Seyyed Mojtaba Mousavi, Dinesh Rokaya , and Kamran Bagheri Lankarani, Chewing Gums as a Drug Delivery Approach for Oral Health. International Journal of Dentistry 2022, 9430988. https://doi.org/10.1155/2022/9430988