Drug Repurposing as an Effective Drug Discovery Strategy
Drug repurposing, or repositioning, has emerged as a pivotal strategy in pharmaceutical research, offering a promising approach to uncover new
Category: Pharma applications
A water-soluble β-cyclodextrin polymer reduces cholesterol accumulation and autophagy dysfunction in vitro and in Niemann-Pick type C disease model mice
A β-CDP (CycloLab) was used for the experiments. The purity of the β-CDP was >95 %. The β-CDP contained <1 % of
Water-Soluble EDTA-Crosslinked Poly-β-Cyclodextrins as Ion-Complexing Drug Carriers.
Water-soluble poly-β-cyclodextrins (PCDs), crosslinked with ethylenediaminetetraacetic acid dianhydride (EDTADA), were synthesized at varying β-CD:EDTADA molar ratios (1:6, 1:9, 1:12, 1:15)
Special issue: Bioadhesive Nanocarriers: Innovations in Drug Release and Therapeutic Effectiveness
Bioadhesive nanocarriers are a notable field for drug delivery, standing out for their ability to combine the advantages of nanotechnology
Cyclodextrin-Based Niosomal Delivery of Imatinib
Lung cancer remains a significant cause of cancer-related deaths globally. The effective cancer treatment aims to deliver drugs that specifically
pH-responsive magnetic cyclodextrin-liposome nanoplatforms for stabilization and targeted delivery of topotecan
Topotecan (TPT), a potent anticancer agent, suffers from rapid hydrolysis of its active lactone ring under physiological conditions, severely limiting
Sugammadex vs. Neostigmine Reversal After Thoracoscopic Thymectomy in Myasthenia Gravis
Rapid and complete reversal of residual neuromuscular blockade (rNMB) is essential for safe postoperative recovery in patients with myasthenia gravis
Cyclodextrin-Driven Drug Deaggregation
The poor aqueous solubility of niclosamide (Nic), a drug with broad therapeutic potential beyond its original antiparasitic use, presents a
Special Issue of the 21st International Cyclodextrin Symposium
The papers from the Special Issue of the 21st International Cyclodextrin Symposium published in Carbohydrate Polymers are available (https://www.sciencedirect.com/special-issue/10BLTS8S758). The
Hydroxypropyl-Beta-Cyclodextrin (HPBCD) inhibits SARS-CoV-2 replication by modulating intracellular lipid dynamics
A multi-year scientific collaboration between Brasilian and American scientists from Federal University at Rio de Janeiro, Brazil, Laboratory of Immunoregulation,