HPBCD in liquid formulations: a systematic study of physical properties and surfactant compatibility
The researchers of TEVA (USA) explored the role of 2-hydroxypropyl-β-cyclodextrin (HPβCD) as an excipient in liquid formulations by evaluating its
Category: Pharma applications
Sulfonated, sulfated thioglycosides and multivalence in heparanase inhibition
Heparan sulfate (HS) analogs are synthetic oligo- and polysaccharides designed to mimic or enhance several biological properties of native HS.
2,6‑di‑O‑methyl‑3‑acetyl‑β‑cyclodextrin: a novel approach to reducde infectivity of SARS‑CoV‑2 and Japanese encephalitis virus
Among 19 CD derivatives studied, pretreatment of viral particles with DMA-β-CyD significantly reduced infectivity (by 2.25–2.67 log₁₀ units after 180
Neuroprotective effects of statins and cyclodextrins: review and potential role in dementia treatment
Dementia is a progressive and irreversible deterioration in cognition that has a significant impact on the person’s activities of daily
Multifunctional biomimetic nanocarriers for the treatment of atherosclerosis
Atherosclerosis (AS) has been considered a systemic disease characterized by the excessive generation of reactive oxygen species (ROS) and the
HPBCD and polysorbate containing formulation to eliminate aggregation of a potent osteogenic protein, recombinant human NELL-1
This study utilized a four-stage rational formulation development approach to mitigate aggregation and stabilize a high molecular weight protein, rhNELL-1.
Cyclodextrin-based carriers for targeted drug delivery, a new review
This post was written by Ibrahim Hussein. Cyclodextrin-based carriers have evolved beyond their traditional role as solubilizing agents toward ligand-targeted,
Selective removal of 7-ketocholesterol by a CD-dimer, a novel atherosclerosis therapeutic candidate
The removal of the toxic oxidized cholesterol, 7-ketocholesterol (7KC), from cells through the administration of therapeutics has the potential to
A host-guest mediated immunomodulatory hydrogel with sustained antibacterial activity for healing of infected diabetic wounds
To solve the hinderance of infected diabetic wound regeneration and healing, an antibacterial and immunomodulatory hydrogel based on host-guest mediated
Dual activity of low-molecular-weight polymeric β-cyclodextrins against tuberculosis
/The biological properties of pβCD of different molecular weights were studied. Strikingly, only the low-molecular-weight pβCD (LMW-pβCD) displayed antibacterial activity,