SBECD, HPBCD and hydrophilic polymers to enhance the solubility of Benzthiazide, Isoxicam, and Piroxicam
The bioavailability of a drug depends, among other parameters, on solubility. One of the strategies used to enhance the solubility
Category: Drug delivery
Caffeine–Hydroxypropyl-β-Cyclodextrin Complex for Skin Treatment
Caffeine is a well-known xanthine that possesses antioxidant effects that could contribute to its application in different skin disorders. In
Cyclodextrin Complexes: A New Hope Against Atherosclerosis
Recently, increasing evidence shows that cyclodextrins have an inhibitory effect against atherosclerosis, a chronic disease inducing atherosclerotic cardiovascular diseases (ASCVDs).
A Piezoelectric and Suture-Free Cardiac Patch Assembled by all FDA-approved Materials Achieves a Minimally Invasive Gene Therapy
Balancing biosafety with multifunctionality remains a critical challenge in biopatch development, impeding clinical translation. This study introduces a minimally invasive
FDA Grants Approval to HPBCD-Enhanced Biologic: A ‘Super-Originator’ Formulation
Cyclodextrin-based super-generics represent enhanced versions of reformulated drug products, offering improved performance and patient outcomes usually developed/marketed by a generic
Recent studies on dimethyl beta-CD
DIMEB (heptakis(2,6-di-O-methyl)-β-cyclodextrin, DMβCD (CYL-4668), was used for improving the solubility of Olmesartan medoxomil (OLM), the prodrug of olmesartan, an angiotensin II
Novel fluorescent CD as theranostic platform for anticancer agents delivery
A novel β-cyclodextrin-aza[5]helicene conjugate as theranostic platform for anticancer agents delivery in cancer cells is reported. The carrier was synthesized
β-Cyclodextrin Encapsulated Platinum(II)-Based Nanoparticles: Photodynamic Therapy and Inhibition of the NF-κB Signaling Pathway in Glioblastoma
This study explores cell death through photodynamic therapy (PDT) with β-cyclodextrin-encapsulated platinum(II)-based nanoparticles (Pt-NPs) and the effect on the NF-κB
Cyclodextrins: Enhancing Drug Delivery, Solubility and Bioavailability for Modern Therapeutics
This review with 238 references explores the multifaceted roles of cyclodextrins in pharmaceutical formulations, ranging from oral, ophthalmic, parenteral, and
45 years of paracetamol (acetaminophen)–beta-cyclodextrin complex history – now used in versatile pharmaceuticals
According to the Cyclodextrin News Library Database, the first description of the paracetamol (acetaminophen)–beta-cyclodextrin complex, published in 1980, is partly