Posted by Atherosclerosis (AS) is a chronic inflammatory disease, which may lead to high morbidity and mortality. Currently, the clinical treatment strategy for AS is administering drugs and performing surgery. However, advanced therapy strategies are urgently required because of the deficient therapeutic effects of current managements. Increased number of energy conversion-based organic or inorganic materials has been used in cancer and other major disease treatments, bringing hope to patients with the development of nanomedicine and materials. These treatment strategies employ specific nanomaterials with specific own physiochemical properties (external stimuli: light or ultrasound) to promote foam cell apoptosis and cholesterol efflux. Based on the pathological characteristics of vulnerable plaques, energy conversion-based nano-therapy has attracted increasing attention in the field of anti-atherosclerosis. Therefore, this review focuses on recent advances in energy conversion-based treatments. In addition to summarizing the therapeutic effects of various techniques, the regulated pathological processes are highlighted. Finally, the challenges and prospects for further development of dynamic treatment for AS are discussed.
There is only one example in this paper mentioning cyclofdextrin: ‘a nanomotor was mainly composed of L-arginine (LA), β-cyclodextrin (β-CD) and Au which had dual-power source. LA induced the generation of NO which could not only work as a driving force but also restore endothelial function and decrease oxidative stress, while Au could provide additional thermophoresis power under irradiation. In vivo, the dual-mode nanomotor showed better enrichment in plaque area than the single-mode one and led to fewer lesions after two months of treatment.’
A quick search in Scopus gave 257 hits for “cyclodextrin” AND “atherosclerosis”, 11 for +photodynamic, 7 for + photothermal and 1 for +sonodynamic key words. It seems that cyclodextrins are not fully explored in energy conversion-based nano-therapies.
Wu G, Yu G, Zheng M, Peng W, Li L. Recent Advances for Dynamic-Based Therapy of Atherosclerosis. Int J Nanomedicine. 2023;18:3851-3878. https://doi.org/10.2147/IJN.S402678