A review on Sulfobutylether-β-cyclodextrin for drug delivery applications

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This review discusses the structure, properties, and preparation methods of SBE-β-CD-based inclusion complexes (ICs). Furthermore, we discuss here the preparation and applications of SBE-β-CD ICs-based nanoparticulate drug delivery systems, which combines the merits of both, ICs (enhanced solubility) and nanoparticles (NPs, targeted therapy). Patents on and FDA-approved Captisol®-enabled products are tabulated in the benefit of readers. The toxicological aspects and current clinical status of SBE-β-CD or SBE-β-CD-based products are briefly explained in the present review. In our opinion, the present review would be a pathfinder to allow dissemination of information on SBE-β-CD.

Chandrakantsing V. Pardeshi, Rucha V. Kothawade, Ashwini R. Markad, Sagar R. Pardeshi, Abhijeet D. Kulkarni, Prashant J. Chaudhari, Marcela R. Longhi, Namdev Dhas, Jitendra B. Naik, Sanjay J. Surana, Mónica C. García: Sulfobutylether-β-cyclodextrin: A functional biopolymer for drug delivery applications,
Carbohydrate Polymers 301, Part B, 2023, 120347.

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