Posted by This article aims to provide a comprehensive, evidence-based overview of the current and potential roles of cyclodextrins as safe, effective, and multifunctional carriers in advanced skincare science. The current state of research on the application of cyclodextrins in cosmeceutical formulations is evaluated, with particular focus on active ingredients commonly used in dermatological care, such as vitamins A and C, coenzyme Q10, kojic acid, arbutin, and UV filters. For each of these compounds, relevant in vitro, in vivo, and clinical studies are reviewed in order to assess how cyclodextrin complexation influences key parameters, including solubility, stability, controlled release, skin penetration, and the reduction in adverse reactions. In addition, the use of cyclodextrins in the treatment of dermatological conditions such as acne, psoriasis, and rosacea is examined, highlighting their potential value, particularly in combination with azelaic acid and salicylic acid, well-known agents used to manage these conditions. Beyond their advantages, the limitations and challenges that currently restrict broader implementation of cyclodextrins in cosmeceuticals are also discussed, including cost variability, solubility constraints with certain substances, formulation incompatibilities, and regulatory considerations. Future perspectives are explored, particularly the development of novel modified and amphiphilic cyclodextrins, as well as their integration into nanotechnology-based systems and into intelligent, personalized skincare.
By examining patents and technical documentation of commercial products, it is possible to identify cosmeceuticals containing CD complexes. SpecialChem, a platform that provides information on a wide variety of cosmetic and dermatological ingredients, lists several examples of such formulations. For instance, four products containing vitamin A complexed with CDs are reported. Similarly, several active agents based on different concentrations of vitamin C complexed with CDs are described, most of which are intended for dermatological preparations and cosmetic products such as night masks and serums. Other compounds analyzed in this work follow a similar pattern of inclusion with CDs: two products contain arbutin, one active agent is based on DHA, a tanning agent providing minimal UV protection, two products contain azelaic acid, and three products contain salicylic acid.
Amaro, C.; Kowalczyk, T.; Picot, L.; Merecz-Sadowska, A.; Verdugo, P.; Cabral-Marques, H.; Sitarek, P. Cyclodextrin-Based Delivery Systems in Cosmeceuticals: Current Advances and Future Perspectives. Biomolecules 2026, 16, 1011. https://doi.org/10.3390/biom16071011