Cyclodextrin (CD) macrocycles are used to create a wide range of supramolecular architectures which are also of interest in applications such as selective gas adsorption, drug delivery, and catalysis. However, predicting their assemblies and identifying the possible isomers in CD oligomers have always remained challenging due to their dynamic nature. Herein, CDs (α, β, and γ) were interacted with a divalent metal ion, Cu2+, to create a series of Cu2+-linked CD oligomers, from dimers to pentamers which were characterized using electrospray ionization mass spectrometry and probed isomerism in each of these isolated oligomers using high resolution trapped ion mobility spectrometry. Using this technique, multiple isomers for each of the Cu2+-interlinked CD oligomers were separated and estimated their relative population, which was not accessible previously using other characterization techniques.
Exploring Isomerism in Isolated Cyclodextrin Oligomers through Trapped Ion Mobility Mass Spectrometry
Papri Chakraborty, Marco Neumaier, Patrick Weis, and Manfred M. Kappes
Cite this: J. Am. Soc. Mass Spectrom. 2023, 34, 4, 676–684
Publication Date:March 23, 2023