Oral Xe-Cyclodextrin for cardiovascular protection

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Cardiac hypertrophy often causes impairment of cardiac function. Xenon (Xe), a naturally occurring noble gas, is known to provide neurological and myocardial protection without side effects. The conventional method of Xe delivery by inhalation is not feasible on a chronic basis. An orally deliverable, effective Xe formulation was developed for long-term administration using 2-hydroxypropyl)-β-cyclodextrin (HPBCD), which was dissolved in water to increase the Xe concentration in solution. The beneficial effects of long-term oral administration of Xe-enriched solutions on cardiovascular function were evaluated in vivo. HPBCD increased Xe solubility from 0.22 mM to 0.67 mM (3.8-fold). Aged ApoE knockout mice fed high-fat diet for 6 weeks developed hypertension, and myocardial hypertrophy with impaired cardiac function. Oral Xe prevented this ischemic damage, preserving normal blood pressure, while maintaining normal left ventricular mass and wall thickness. This novel formulation allows for gastrointestinal delivery and cardiovascular stabilization.

Yin X, Moody MR, Hebert V, Klegerman ME, Geng YJ, Dugas TR, McPherson DD, Kim H, Huang SL. Oral delivery of xenon for cardiovascular protection. Sci Rep. 2019 Oct 1;9(1):14035. doi: 10.1038/s41598-019-50515-3

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