An Updated Overview of Cyclodextrin-Based Drug Delivery Systems for Cancer Therapy

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Cancer denotes a group of more than a hundred types of diseases characterized by the malignant form of abnormal tissue growth in different body parts. As one of the leading causes of morbidity and mortality worldwide, cancer remains an ongoing challenge for the healthcare system, requiring prompt and adequate treatment to prevent severe health problems, prolong patients’ survival rates, and improve their life quality. Despite the existence and clinical use of several chemotherapeutic drugs, their application is restricted due to unfavorable physicochemical properties (e.g., poor aqueous solubility, photolability, unpleasant smell) and hard-to-maintain balance between efficacy and systemic adverse side effects. In this work some of the newest advancements in the CD-based drug delivery systems holding promise in treating the most common or deadly types of cancer are reviewed.

A series of nanosystems functionalized with targeting ligands, pH-responsive structures, photolabile compounds, magnetic nanoparticles, and various enzymes have been reported with promising results. CD-based drug delivery systems were tested against many types of cancer, demonstrating encouraging anti-tumor activity in in vitro and in vivo tests.

Păduraru DN, Niculescu AG, Bolocan A, Andronic O, Grumezescu AM, Bîrlă R. An Updated Overview of Cyclodextrin-Based Drug Delivery Systems for Cancer Therapy. Pharmaceutics. 2022 Aug 22;14(8):1748. doi: 10.3390/pharmaceutics14081748.

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