Posted by A recently published book titled “Applications of Polymer Nanofibers” (Wiley, 2022) contains a chapter on “Electrospun Nanofibers for Drug Delivery Applications”. This chapter covers the delivery of various molecules like hydrophilic and hydrophobic drugs, proteins, enzymes, and growth factors from nanofibers produced by blend, coaxial, and emulsion electrospinning techniques. More importantly, this chapter includes the studies of Dr. Uyar’s research group regarding the use of cyclodextrins (CDs) in drug delivery applications. Inclusion complexes (ICs) of CDs and small molecules can be incorporated into polymer solutions before electrospinning process or ICs of CDs can be exploited as a template for nanofiber formation using electrospinning.
When CD-ICs are incorporated into a variety of polymeric nanofibers they can act as delivery platforms by providing controlled release and enhanced solubility of small molecules encapsulated into CDs [1-7]. CDs can also form nanofibers at their highly concentrated solutions thanks to the formation of self-assembly and aggregates. Therefore, non-polymeric nanofibers composed of CD-ICs of numerous molecules can be developed as fast dissolving drug delivery systems [8-25]. Last but not the least, non-spinnable CD-ICs solutions can also be used in the core of the core-shell nanofibers and provide slower release of molecules to be delivered [26].
[1] Aytac, Z. and Uyar, T. (2016). Antioxidant activity and photostability of α-tocopherol/β-cyclodextrin inclusion complex encapsulated electrospun polycaprolactone nanofibers. European Polymer Journal 79: 140–149.
[2] Aytac, Z., Dogan, S.Y., Tekinay, T., and Uyar, T. (2014). Release and antibacterial activity of allyl isothiocyanate/β-cyclodextrin complex encapsulated in electrospun nanofibers. Colloids and Surfaces B: Biointerfaces 120: 125–131.
[3] Aytac, Z., Sen, H.S., Durgun, E., and Uyar, T. (2015). Sulfisoxazole/cyclodextrin inclusion complex incorporated in electrospun hydroxypropyl cellulose nanofibers as drug delivery system. Colloids and Surfaces B: Biointerfaces 128: 331–338.
[4] Aytac, Z., Kusku, S.I., Durgun, E., and Uyar, T. (2016a). Encapsulation of gallic acid/ cyclodextrin inclusion complex in electrospun polylactic acid nanofibers: release behavior and antioxidant activity of gallic acid. Materials Science and Engineering C 63: 231–239.
[5] Aytac, Z., Kusku, S.I., Durgun, E., and Uyar, T. (2016b). Quercetin/β-cyclodextrin inclusion complex embedded nanofibres: slow release and high solubility. Food Chemistry 197: 864–871.
[6] Aytac, Z., Ipek, S., Durgun, E. et al. (2017a). Antibacterial electrospun zein nanofibrous web encapsulating thymol/cyclodextrin-inclusion complex for food packaging. Food Chemistry 233: 117–124.
[7] Aytac, Z., Keskin, N.O.S., Tekinay, T., and Uyar, T. (2017b). Antioxidant α- tocopherol/γ-cyclodextrin–inclusion complex encapsulated poly(lactic acid) electrospun nanofibrous web for food packaging. Journal of Applied Polymer Science 134 (21); 44858 (1–9).
[8] Aytac, Z., Yildiz, Z.I., Kayaci-Senirmak, F. et al. (2016c). Fast-dissolving, prolonged release, and antibacterial cyclodextrin/limonene-inclusion complex nanofibrous webs via polymer-free electrospinning. Journal of Agricultural and Food Chemistry 64 (39): 7325–7334.
[9] Aytac, Z., Yildiz, Z.I., Kayaci-Senirmak, F. et al. (2016d). Electrospinning of polymer-free cyclodextrin/geraniol–inclusion complex nanofibers: enhanced shelf-life of geraniol with antibacterial and antioxidant properties. RSC Advances 6 (52): 46089–46099.
[10] Aytac, Z., Yildiz, Z.I., Kayaci-Senirmak, F. et al. (2017c). Electrospinning of cyclodextrin/linalool-inclusion complex nanofibers: fast-dissolving nanofibrous web with prolonged release and antibacterial activity. Food Chemistry 231: 192–201.
[11] Aytac, Z., Celebioglu, A., Yildiz, Z.I., and Uyar, T. (2018). Efficient encapsulation of citral in fast-dissolving polymer-free electrospun nanofibers of cyclodextrin inclusion complexes: high thermal stability, longer shelf-life, and enhanced water solubility of citral. Nanomaterials 8 (10): 793.
[12] Celebioglu, A. and Uyar, T. (2017). Antioxidant vitamin E/cyclodextrin inclusion complex electrospun nanofibers: enhanced water solubility, prolonged shelf life, and photostability of vitamin E. Journal of Agricultural and Food Chemistry 65 (26): 5404–5412.
[13] Celebioglu, A. and Uyar, T. (2019a). Encapsulation and stabilization of α-lipoic acid in cyclodextrin inclusion complex electrospun nanofibers: antioxidant and fast-dissolving α-lipoic acid/cyclodextrin nanofibrous webs. Journal of Agricultural and Food Chemistry 67 (47): 13093–13107.
[14] Celebioglu, A. and Uyar, T. (2019b). Fast dissolving oral drug delivery system based on electrospun nanofibrous webs of cyclodextrin/ibuprofen inclusion complex nanofibers. Molecular Pharmaceutics 16 (10): 4387–4398.
[15] Celebioglu, A. and Uyar, T. (2019c). Metronidazole/hydroxypropyl-β-cyclodextrin inclusion complex nanofibrous webs as fast-dissolving oral drug delivery system. International Journal of Pharmaceutics 572: 118828.
[16] Celebioglu, A. and Uyar, T. (2020). Hydrocortisone/cyclodextrin complex electrospun nanofibers for a fast-dissolving oral drug delivery system. RSC Medicinal Chemistry 11 (2): 245–258.
[17] Celebioglu, A., Aytac, Z., Kilic, M.E. et al. (2018a). Encapsulation of camphor in cyclodextrin inclusion complex nanofibers via polymer-free electrospinning: enhanced water solubility, high temperature stability, and slow release of camphor. Journal of Materials Science 53 (7): 5436–5449.
[18] Celebioglu, A., Yildiz, Z.I., and Uyar, T. (2018b). Electrospun nanofibers from cyclodextrin inclusion complexes with cineole and p-cymene: enhanced water solubility and thermal stability. International Journal of Food Science and Technology 53 (1): 112–120.
[19] Yildiz, Z.I., Celebioglu, A., and Uyar, T. (2017). Polymer-free electrospun nanofibers from sulfobutyl ether7-beta-cyclodextrin (SBE7-β-CD) inclusion complex with sulfisoxazole: fast-dissolving and enhanced water-solubility of sulfisoxazole. International Journal of Pharmaceutics 531 (2): 550–558.
[20] Yildiz, Z.I. and Uyar, T. (2019). Fast-dissolving electrospun nanofibrous films of paracetamol/cyclodextrin inclusion complexes. Applied Surface Science 492: 626–633.
[21] Yildiz, Z.I., Celebioglu, A., Kilic, M.E. et al. (2018a). Menthol/cyclodextrin inclusion complex nanofibers: enhanced water-solubility and high-temperature stability of menthol. Journal of Food Engineering 224: 27–36.
[22] Yildiz, Z.I., Celebioglu, A., Kilic, M.E. et al. (2018b). Fast-dissolving carvacrol/ cyclodextrin inclusion complex electrospun fibers with enhanced thermal stability, water solubility, and antioxidant activity. Journal of Materials Science 53 (23): 15837–15849.
[23] Yildiz, Z.I., Kilic, M.E., Durgun, E., and Uyar, T. (2019). Molecular encapsulation of cinnamaldehyde within cyclodextrin inclusion complex electrospun nanofibers: fast-dissolution, enhanced water solubility, high temperature stability, and antibacterial activity of cinnamaldehyde. Journal of Agricultural and Food Chemistry 67 (40): 11066–11076.
[24] Celebioglu, A., Yildiz, Z.I., and Uyar, T. (2018c). Fabrication of electrospun eugenol/ cyclodextrin inclusion complex nanofibrous webs for enhanced antioxidant property, water solubility, and high temperature stability. Journal of Agricultural and Food Chemistry 66 (2): 457–466.
[25] Celebioglu, A., Yildiz, Z.I., and Uyar, T. (2018d). Thymol/cyclodextrin inclusion complex nanofibrous webs: enhanced water solubility, high thermal stability and antioxidant property of thymol. Food Research International 106: 280–290.
[26] Aytac, Z. and Uyar, T. (2017). Core–shell nanofibers of curcumin/cyclodextrin inclusion complex and polylactic acid: enhanced water solubility and slow release of curcumin. International Journal of Pharmaceutics 518 (1–2): 177–184.