When Cyclodextrins Met Data Science: Unveiling Their Pharmaceutical Applications through Network Science and Text-Mining

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This review of Rincón-López et al. (2021) was published in the special issue Pharmaceutical and Biomedical Applications of Cyclodextrins and Derivatives (eds. Ferenc Fenyvesi and Judit Váradi).

This work is the first unsupervised/supervised data-mining approach aimed at depicting a landscape of CDs to identify trending and emerging technologies and uncover opportunity areas in CD pharmaceutical research. The results showed that most CD pharmaceutical patents were associated with the development of aqueous solutions for parenteral or local administration. The data underlined the significance of CDs in tablets, and powders, too. Additionally, they highlighted the role of CDs in formulations of anti-inflammatory drugs, cancer therapies, and antiviral strategies. Text-mining showed that the trends in CDs for aqueous solutions, tablets, and powders are going upward. Gels seem to be promising, while patches and fibers are emerging. Cyclodextrins’ potential in suspensions and emulsions is yet to be recognized and can become an opportunity area.

Pharmaceutics 13 01297 g006

The authors also cite the Cyclodextrin News:

Sohajda, T. Cyclo Therapeutics Announces Design of Pivotal Phase 3 Study Evaluating Trappsol® CycloTM in Niemann-Pick Type C1. Available online: https://cyclodextrinnews.com/2021/04/29/cyclo-therapeutics-announces-design-of-pivotal-phase-3-study-evaluating-trappsol-cyclo-in-niemann-pick-type-c1/ (accessed on 7 July 2021).

Puskás, I. Cyclodextrin News: HPβCD Is a Unique Component in Janssen’s COVID-19 Vaccine Candidate. Available online: https://cyclodextrinnews.com/2021/02/25/hpbcd-is-a-unique-component-in-janssens-covid-19-vaccine-candidate/ (accessed on 6 July 2021).

Rincón-López J, Almanza-Arjona YC, Riascos AP, Rojas-Aguirre Y. When Cyclodextrins Met Data Science: Unveiling Their Pharmaceutical Applications through Network Science and Text-Mining. Pharmaceutics. 2021;13(8):1297. Published 2021 Aug 19. doi:10.3390/pharmaceutics13081297

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