Ester-Bridged β-Cyclodextrin Nanosponges: Effect of the Cross-Linking Density

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The cross-linking density influences the physicochemical properties of cyclodextrin-based nanosponges (CD-NSs) used for various purposes including drug delivery. Although the effect of the cross-linker type and content on the NSs performance has been investigated, a detailed study of the cross-linking density has never been performed.
In this contribution, nine ester-bridged NSs based on β-cyclodextrin (β-CD) and different quantities
of pyromellitic dianhydride (PMDA), used as a cross-linking agent in stoichiometric proportions of 2, 3, 4, 5, 6, 7, 8, 9, and 10 moles of PMDA for each mole of CD, were synthesized and characterized in terms of swelling and rheological properties. The results, from the swelling experiments, exploiting Flory–Rehner theory, and rheology, strongly showed a cross-linker content-dependent behavior. The study of cross-linking density allowed to shed light on the efficiency of the synthesis reaction methods. Overall, the study demonstrates that by varying the amount of cross-linking agent, the cross-linked structure of the NSs matrix can be controlled effectively.

Hoti, G.; Caldera, F.; Cecone, C.; Rubin Pedrazzo, A.; Anceschi, A.; Appleton, S.L.; Khazaei Monfared, Y.; Trotta, F (2021) Effect of the Cross-Linking Density on the Swelling and Rheological Behavior of Ester-Bridged β-Cyclodextrin Nanosponges. Materials 14, 478.

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