Alpha-cyclodextrin improves water transport, cell hydration and longevity

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The potential effects of alpha-CD on cellular water uptake and aging were studied. Two independent in vivo biological test systems were used, a single cell Xenopus oocyte with expressed human aquaporin for cell hydration studies and the nematode Caenorhabditis elegans for testing life span in the treated animals. a-CD was found to enhance water uptake through aquaporins of oocytes.

 It was also observed that the CD treated C. elegans showed a considerable increase in vitality during the mid-point of their lives. These results demonstrated that concentrations below 0.1% perform better compared to higher concentrations, and the authors believe that this is correlated with a decrease in aqueous density that was also observed. 

Together, these results raise a rational for assaying a-CD as a potent drug candidate in treating various age-related diseases.

Alpha-CD extends C. elegans mean life span. Mean life span of nematodes treated with 0.05, 0.50 w/v% (A) and 0.10 w/v% (B) a-CD-containing water samples.

Szente L, Puskás I, Vellai T, Lohmann H (2021) Effects of alpha-cyclodextrin on water transport, cell hydration and longevity. Aging, 13, 202533. DOI: 10.18632/aging.202533

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