J. Colloid Interface Sci. recently published an article reporting the development of fast-dissolving CD/antibiotics inclusion complex (IC) nanofibers for oral delivery. The authors produced uniform nanofibers from CD/antibiotics complexes through electrospinning using water as the solvent. High loadings of antibiotics (gentamicin, kanamycin, ampicillin, and chloramphenicol) was confirmed by both NMR and TGA analyses, while the formation of inclusion complexes was mainly confirmed by XRD measurements with the disappearance of crystalline peaks of the antibiotics in the fibers.
The CD/antibiotic nanofibers rapidly dissolved in artificial saliva because of their hydrophilic structure. The fibers showed high antibacterial activity against Gram-negative E. coli even at as low as 1:0.05 molar ratio, demonstrating that the CD could efficiently host antibiotics in its cavity, while preserving their stability. These waterborne nanofibrous materials have great potential to be employed for oral delivery of antibiotics, while the un-complexed CD molecules could be employed for the loading of other drug molecules.
F. Topuz, M.E. Kilic, E. Durgun, G. Szekely, Fast-dissolving antibacterial nanofibers of cyclodextrin/antibiotic inclusion complexes for oral drug delivery, J. Colloid Interface Sci., 2021, 585, 184–194.