Cyclodextrins against skin aging

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Since the last review in the Cyclodextrin News summarizing the anti aging effects of retinol (Vitamin A) and its derivatives, tocopherol (Vitamin E) and ubiquinone (Vitamin Q10) solubilized/stabilized by CDs the following trends were highlighted in the literature:

  • Improving skin penetration of hyaluronic acid (anti-wrinkle compound) by using quaternized cyclodextrin grafted chitosan [1]
  • Promoting skin permeation of isoflavones such as formononetin by HPBCD [2]
  • Solubilizing/stabilizing epidermal growth factor (EGF) and vitamin E acetate in liposome formulation [3]
  • Solubilizing/stabilizing cosmeceutical ingredients derived from plants [4] such as lotus seed extract [5], camellia oleifera [6], grape seed extract [7]
  • Improving the properties of solid lipid nanoparticles used as skin delivery systems for natural antioxidants such as resveratrol by using tetradecyl BCD [8]



  1. Sakulwech, S., Lourith, N., Ruktanonchai, U., Kanlayavattanakul, M. Preparation and characterization of nanoparticles from quaternized cyclodextrin-grafted chitosan associated with hyaluronic acid for cosmetics. Asian Journal of Pharmaceutical Sciences, 2018, 13(5), 498-504
  2. Dias, P.H., Scopel, M., Martiny, S., Bianchi, S.E., Bassani, V.L., Zuanazzi, J.A.S. Hydroxypropyl-β-cyclodextrin-containing hydrogel enhances skin formononetin permeation/retention. Journal of Pharmacy and Pharmacology, 2018, 70(7), 865-873
  3. Chai, Y., Huang, H. EGF/vitamin E acetate-cyclodextrin liposome as well as preparation method, use method and application thereof. CN107789207, 2018
  4. Charles Dorni, A.I., Amalraj, A., Gopi, S., Varma, K., Anjana, S.N. Novel cosmeceuticals from plants—An industry guided review. Journal of Applied Research on Medicinal and Aromatic Plants, 2017, 7, 1-26
  5. Zhang Y. Skincare rich-hydrogen water composition and production process and application thereof to cosmetics. CN108143659, 2018
  6. Wu, S., Song, B., Liu, R. Camellia oleifera component based body lotion and preparation method thereof. CN106667837, 2017
  7. Liu, Y. Natural plant beuty cosmetics. CN106361639, 2017
  8. Costa, R., Santos, L. Delivery systems for cosmetics – From manufacturing to the skin of natural antioxidants. Powder Technology, 2017, 322, 402-416

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