Starting from the discovery of cyclodextrins (“cellulosines” at that time) by Villiers in 1891 the history of cyclodextrin research is overviewed in the video on the CyclonHit project website. The main stages are as follows:
Period of discovery : 1891-1935
Period of exploration: 1935-1970
Period of utilization: 1970-
The big names (Schardinger, French, Cramer, Szejtli, etc) are mentioned with their contribution to the knowledge on cyclodextrins.
The main properties of the cyclodextrin derivatives produced industrially are summarized with special emphasis on the role of degree of substitution.