Toxic effects and cellular uptake of functional polyrotaxanes.
The little we have learned and the many unknowns still waiting to be discovered. Cyclodextrins are commonly used as excipients
Tag: polyrotaxane
Topologically-crosslinked hydrogels based on γ-cyclodextrins
Biomimetic strategies are increasingly the focus of materials scientists looking to improve or invent new materials. Topology is an important
Cyclodextrin-based rotaxanes as a versatile platform for biological and medicinal applications
Mechanically interlocked molecules (MIMs) such as rotaxanes and catenanes attract significant interest due to their unique structures and dynamic properties.
Cyclodextrin-Based Supramolecular Carrier for Cancer Proteinaceous Antigen
Protein-based vaccines are gaining attention as a promising platform for vaccines because they are highly safe and induce humoral and
Supramolecular polyrotaxane-based nano-theranostics enable cancer-cell stiffening for enhanced T-cell-mediated anticancer immunotherapy
Redox-responsive Methyl-β-cyclodextrin (MeβCD)-based supramolecular polyrotaxanes (MSPs) were fabricated: the amphiphilic diselenide-bridged axle polymer was loaded by MeβCD via the host-guest
Preparation and Application of Polyrotaxane Cross-Linking Agent Based on Cyclodextrin in Gel Materials Field
The cross-linking point of a conventional chemical cross-linking agent is fixed. Therefore, gels that are prepared with a conventional cross-linking
Differences in the Intracellular Localization of Methylated β-Cyclodextrins-Threaded Polyrotaxanes Lead to Different Cellular States
Activation of autophagy represents a potential therapeutic strategy for the treatment of diseases that are caused by the accumulation of
Cothreading of Unmodified and Monoazidated β-Mixed cyclodextrins in polyrotaxanes for Niemann Pick disease
To establish a method for the orthogonal chemical functionalization of β-cyclodextrin (β-CD)-based polyrotaxane (PRX), unmodified and monoazidated β-CDs (N3-β-CDs) were
γ-Cyclodextrin-based polypseudorotaxane hydrogels for ophthalmic delivery of flurbiprofen to treat anterior uveitis
Anterior uveitis is a sight-threatening inflammation inside the eyes. Conventional eye drops for anti-inflammatory therapy need to be administered frequently
Weakly acidic carboxy group-grafted β-cyclodextrin-threaded acid-degradable polyrotaxanes for modulating protein interaction and cellular internalization
To improve the therapeutic potential of β-cyclodextrin (β-CD)-threaded acid-degradable polyrotaxanes (β-CD PRXs) in cholesterol-related metabolic disorders, the effect of carboxylation