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Tag: HPGCD

October 11, 2022 CD as API / Pharma applications

Inclusion Solves Insolubility ―Translational Research Cycle from Bedside to Bench and Bench to Bedside for Drug Development Targeting Niemann-Pick Disease Type C

Cyclodextrins (CDs) are used not only as pharmaceutical excipients but also as active pharmaceutical ingredients. CDs can act as artificial

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February 21, 2022 Drug delivery / Pharma applications

Encapsulation of a contrasting agent (closo-dodecaiodododecaborate) in HP-γ-CD prevents hemolysis

Na2B12I12 has many of the properties desired by an X-ray contrast agent but is lethal at the concentrations needed for medical

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November 30, 2021 CD derivatives / Life sciences

Cyclodextrins Exert a Ligand-like Current Inhibitory Effect on the KV1.3 Ion Channel Independent of Membrane Cholesterol Extraction

Effects of CDs exerted on cellular functions are generally thought to originate from reductions in cholesterol levels. Potential direct, ligand-like

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July 12, 2021 Drug delivery / Pharma applications

Nanofibrous Formulation of Cyclodextrin Stabilized Lipases for Efficient Pancreatin Replacement Therapies

The purpose of enzyme therapies (ERT) is simple: patients who suffer from enzyme deficiency should be treated by administering enzymes

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March 4, 2020 Food

Fast-dissolving antioxidant curcumin/cyclodextrin inclusion complex electrospun nanofibrous webs

Curcumin/Hydroxypropyl-beta-Cyclodextrin (HP-β-CD) and Curcumin/Hydroxypropyl-gamma-Cyclodextrin (HP-γ-CD) inclusion complex nanofibrous webs were produced using electrospinning technique for the purpose of orally fast-dissolving

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January 15, 2019 Drug delivery

Antibiotics degradation products against Alzheimer’s disease

A recent paper in Cell Reports published an interesting finding: polymeric degradation products (compound X and Z, respectively) of antibiotics

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August 30, 2018 CD as API / Pharma applications

Different cyclodextrins to treat NPC

If you are following advances in the re-discovery of cyclodextrins as APIs, there is quite a race among the candidates

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Recent Posts

  • Special Issue “Cyclodextrin-Functionalized Materials for Drug Delivery, Pharmaceutical and Medical Applications”
  • Cyclodextrin-Based Oral Solution of Ursodeoxycholic Acid Using a Ready-to-Use Vehicle
  • Cyclodextrin-based electrochemical sensors for PFAS detection
  • FDA: Inclusion complex of a GRAS guest and a GRAS host is also GRAS
  • HPBCD for the treatment of irreversible white matter injury

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Top Posts

  • Molecular-level enhanced clusterization-triggered emission of nonconventional luminophores in dilute aqueous solution
  • 4th International Biotechnology Congress 2020
  • Remdesivir interactions with sulfobutylether-b-cyclodextrins: A case study using selected substitution patterns
  • Methyl BCD for axon regeneration after injury - PNAS cover paper
  • The scent of Christmas tree
  • Effects of β-cyclodextrin bead polymer on the quality of wines
  • Complexation of cholesterol with β-cyclodextrin derivatives: A combined theoretical and experimental study
  • Cyclodextrin complexation of selected tyrosine kinase inhibitors
  • New book: Host-Guest Polymer Complexes
  • Treatment of Niemann-Pick Disease Type C using crosslinked 2-hydroxypropyl-β-cyclodextrin

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