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Tag: cholesterol depletion

January 27, 2026 CD as API / Pharma applications

A water-soluble β-cyclodextrin polymer reduces cholesterol accumulation and autophagy dysfunction in vitro and in Niemann-Pick type C disease model mice

A β-CDP (CycloLab) was used for the experiments. The purity of the β-CDP was >95 %. The β-CDP contained <1 % of

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December 23, 2025 CD as API / CD derivatives / Pharma applications

Multifunctional biomimetic nanocarriers for the treatment of atherosclerosis

Atherosclerosis (AS) has been considered a systemic disease characterized by the excessive generation of reactive oxygen species (ROS) and the

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September 8, 2025 Uncategorized

α-CD Derivatives: Low Efficacy and Ototoxicity in NPC Models

HP-β-CD is currently under clinical investigation for treating Niemann-Pick disease type C (NPC), but its ototoxicity remains problematic. It was

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June 24, 2025 CD as API / Pharma applications

Cholesterol Depletion by Cyclodextrins Reduces Pain Sensation

The nociceptive Transient Receptor Potential Vanilloid 1 (TRPV1) and Ankyrin 1 (TRPA1) channels are predominantly expressed on peptidergic sensory nerves,

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July 15, 2022 Food / Non-pharma applications

β-Cyclodextrin as the Key Issue in Production of Acceptable Low-Cholesterol Dairy Products

The application of cyclodextrins in food technology is extensive due to their unique ability to form complexes with many bioactive

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January 26, 2022 CD as API / CD derivatives / Pharma applications

Poly-β-cyclodextrin Supramolecular Nanoassembly with a pH-Sensitive Switch Removing Lysosomal Cholesterol Crystals for Antiatherosclerosis

Cholesterol crystals (CCs), originally accumulating in the lysosome of cholesterol-laden cells, can aggravate the progression of atherosclerosis. β-cyclodextrin (CD) is

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November 29, 2021 CD derivatives / Drug delivery / Pharma applications

Synthesis and biological evaluation of novel β-cyclodextrin-fluvastatin conjugates

Drugs that may regulate lipid metabolism and lower cholesterol, such as statins (drugs that reduce de novo cholesterol synthesis) or

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October 7, 2021 CD as API / Pharma applications

Visualization of cholesterol depletion at the plasma membrane by methyl-β-cyclodextrin

The most common method to modify cellular cholesterol content in vitro is to incubate cells with cyclodextrin (CD). However, it

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April 23, 2020 CD as API

Novel example for the antiviral effect of methyl beta-CD

MβCD was found again to have antiviral effect, but in this case the Chinese scientists found that the cholesterol removal

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April 14, 2020 Pharma applications / Uncategorized

Modulation of Plasma Membrane Composition and Microdomain Organization by methyl beta-CD in B16-F10 Mouse Melanoma Cells

The most interesting finding of Crui et al. in their recently published paper [1] for the readers of the Cyclodextrin

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Recent Posts

  • Environment-Sensitive Fluorophores Report on Structural Organization of Biological Membranes at Various Depths
  • A Cyclodextrin Surprise in a Japanese Supplement
  • Modifying the interior cavity of cyclodextrin
  • Special issue: Novel macrocycles: from synthesis to supramolecular function
  • Chitosan-coated cyclodextrin-based niosomes enable enhanced nose-to-brain delivery of rivastigmine and asiaticoside for Alzheimer’s disease

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Top Posts

  • A Cyclodextrin Surprise in a Japanese Supplement
  • Modifying the interior cavity of cyclodextrin
  • Environment-Sensitive Fluorophores Report on Structural Organization of Biological Membranes at Various Depths
  • HPBCD in an approved non-replicating adenoviral vector-based gene therapy product
  • Chitosan-coated cyclodextrin-based niosomes enable enhanced nose-to-brain delivery of rivastigmine and asiaticoside for Alzheimer's disease
  • How air fresheners work?
  • 22nd International Cyclodextrin Symposium (ICS-22) in India
  • FDA Grants Approval to HPBCD-Enhanced Biologic: A 'Super-Originator' Formulation
  • New FDA approved medicinal product containing Betadex sulfobutylether sodium: VYKOURA
  • Practical Considerations about the Cyclodextrin Solubilities – A Quickstart Guide for Newbies

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