Methyl BCD alters cell envelop studied by AFM
To elucidate the involvement of the cell envelope in the stiffness of sickle cells, methyl-β-cyclodextrin (MβCD), a putative cholesterol-depleting reagent
Tag: Cell membrane
Veklury® (remdesivir) formulations inhibit initial membrane-coupled events of SARS-CoV-2 infection due to their sulfobutylether-β-cyclodextrin content
Background and purpose: Despite its contradictory clinical performance, Veklury® (remdesivir) has a pivotal role in COVID-19 therapy. Possible contributions of the
Integration of cyclodextrins and associated toxicities: A roadmap for high quality biomedical applications
Cyclodextrins are extensively employed in drug delivery systems like inclusion complexes, metal-organic frameworks, functionalized or PEGylated conjugates, and other nanocarrier
Polypeptide-Shelled Cyclodextrin-Containers for Intracellular Delivery of Membrane-Impermeable Cargo
The transport of membrane impermeable compounds into cells is a prerequisite for the efficient cellular delivery of hydrophilic and amphiphilic
Methyl alpha-CD for lipid exchange in cell membrane
Methods for efficient cyclodextrin-induced lipid exchange have been developed in our lab. These make it possible to almost completely replace
Visualization of cholesterol depletion at the plasma membrane by methyl-β-cyclodextrin
The most common method to modify cellular cholesterol content in vitro is to incubate cells with cyclodextrin (CD). However, it
Weakly acidic carboxy group-grafted β-cyclodextrin-threaded acid-degradable polyrotaxanes for modulating protein interaction and cellular internalization
To improve the therapeutic potential of β-cyclodextrin (β-CD)-threaded acid-degradable polyrotaxanes (β-CD PRXs) in cholesterol-related metabolic disorders, the effect of carboxylation
Is CD shuttle or sink for cholesterol?
A Chinese group has recently published [1] their interesting findings: in atherosclerosis β-CD (probaly methyl beta-cyclodextrin, but not specified) was
Methyl-β-cyclodextrin, an actin depolymerizer augments the antiproliferative potential of microtubule-targeting agents
The effect of Methyl BCD (RAMEB) on cytoskeleton was studied. It was found that disassembling the actin network did not
Manipulation of cell membrane phospholipids by methylated alpha-CD
Methylated α-CD (MeACD) loaded with exogenous lipids was used to replace the endogenous phospholipids and sphingolipids from cell plasma membrane