Disruption of Lipid Sorting and Endosomal Transport in Cyclodextrin-mediated Cytotoxicity
The effects of native and modified CDs in human renal proximal tubule cells was studied using complementary imaging, flow cytometry,
Tag: Cell membrane
Sickle cell anemia and cyclodextrins
(The very first report on the beneficial consequence of cyclodextrin-assisted cholesterol removal from red blood cell membranes.) Sickle cell anemia
Cell Membrane-Coated Nanoparticles for Precision Medicine
Nanoencapsulation has become a recent advancement in drug delivery, enhancing stability, bioavailability, and enabling controlled, targeted substance delivery to specific
Methyl BCD alters cell envelop studied by AFM
To elucidate the involvement of the cell envelope in the stiffness of sickle cells, methyl-β-cyclodextrin (MβCD), a putative cholesterol-depleting reagent
Veklury® (remdesivir) formulations inhibit initial membrane-coupled events of SARS-CoV-2 infection due to their sulfobutylether-β-cyclodextrin content
Background and purpose: Despite its contradictory clinical performance, Veklury® (remdesivir) has a pivotal role in COVID-19 therapy. Possible contributions of the
Integration of cyclodextrins and associated toxicities: A roadmap for high quality biomedical applications
Cyclodextrins are extensively employed in drug delivery systems like inclusion complexes, metal-organic frameworks, functionalized or PEGylated conjugates, and other nanocarrier
Polypeptide-Shelled Cyclodextrin-Containers for Intracellular Delivery of Membrane-Impermeable Cargo
The transport of membrane impermeable compounds into cells is a prerequisite for the efficient cellular delivery of hydrophilic and amphiphilic
Methyl alpha-CD for lipid exchange in cell membrane
Methods for efficient cyclodextrin-induced lipid exchange have been developed in our lab. These make it possible to almost completely replace
Visualization of cholesterol depletion at the plasma membrane by methyl-β-cyclodextrin
The most common method to modify cellular cholesterol content in vitro is to incubate cells with cyclodextrin (CD). However, it
Weakly acidic carboxy group-grafted β-cyclodextrin-threaded acid-degradable polyrotaxanes for modulating protein interaction and cellular internalization
To improve the therapeutic potential of β-cyclodextrin (β-CD)-threaded acid-degradable polyrotaxanes (β-CD PRXs) in cholesterol-related metabolic disorders, the effect of carboxylation