Posted by Hydrophobic deep eutectic solvents (HDESs) can serve as pseudostationary phases (PSPs) in capillary electrophoresis (CE). Their integration into conventional chiral CE methodologies, such as cyclodextrin-based electrokinetic chromatography, demonstrates a synergistic effect that notably enhances chiral separation efficiency. This chapter presents an example elucidating the enantioseparation of four azole antifungal drugs (tioconazole, isoconazole, miconazole, and econazole) employing carboxymethyl-β-cyclodextrin and the HDES methyltrioctylammonium chloride-octanoic acid.
Zhang, Q., Xue, S., Xu, Y. (2026). Chiral Separation in Capillary Electrophoresis Using Cyclodextrins in Combination with Hydrophobic Deep Eutectic Solvents. In: Scriba, G.K.E., Chankvetadze, B. (eds) Chiral Separations. Methods in Molecular Biology, vol 2994. Humana, New York, NY. https://doi.org/10.1007/978-1-0716-5023-3_20