Posted by Cancer nanomedicine holds transformative potential, but its clinical translation remains hindered by the lack of preclinical models that accurately mimic human tumor complexity. Conventional approaches often overlook the dynamic tumor microenvironment (TME) and interpatient variability, leading to unreliable predictions of nanodrug behavior. Here, we present tumor organoids as a transformative solution. These three-dimensional cultures retain the original tumor’s architecture, molecular profiles, and TME interactions. Through concrete examples spanning pancreatic, breast, and glioblastoma cancers, it is shown how organoids reliably evaluate nanodrug delivery efficiency, therapeutic effects, and safety profiles [1].
The paper [1] does not mention any examples where a cyclodextrin mediated drug was studied by the organoids. Based on Scopus search the following studies used CD-enabled formulations in organoid tumor models:
| Organoid | Drug | CD | Result | Ref. |
| Lung cancer (150–1000 KPT-LUAD cells, Advanced DMEM/F12 (Gibco) , Matrigel | LGK974 | ACD, BCD, HPBCD, SBE-ACD, SBE-BCD | Enhanced biological activity, especially with HPBCD and SBE-BCD | [2] |
| Parkinson disease brain model | HPBCD | increasing autophagy, mitophagy | [3] | |
| chondroid tumor model | BCD | BCD-PNIPAm hydrogel as a nest for adipose derived stem cell spheroids and chondrocytes for 3D printing of organoid culture | [4] | |
| Cerebral organoid model | MeBCD | Pretreatment of cells with MeBCD before infecting with Dengue virus-2 | [5] |
References
[1] Chen L, Luo X, Zhang J, Zhang J, Yang C, Zhao Y. Harnessing Organoid Platforms for Nanoparticle Drug Development. Drug Des Devel Ther. 2025;19:6125-6143
https://doi.org/10.2147/DDDT.S530999
[2] Gimaraes, P.P.G. et al. (2018) Potent in vivo lung cancer Wnt signaling inhibition via cyclodextrin-LGK974 inclusion complexes. J. Contr. Rel. 290, 75–87 https://doi.org/10.1016/j.jconrel.2018.09.025
[3] jarazo, J. et al. (2022) Parkinson’s disease phenotypes in patient neuronal cultures and brain organoids improved by 2-hydroxypropyl-β-cyclodextrin treatment. Movement Disorders 37, 80–94 https://doi.org/10.1002/mds.28810
[4] Zhang L, et al., (2022) Solid multifunctional granular bioink for constructing chondroid basing on stem cell spheroids and chondrocytes. Biofabrication. 2022 Apr 13;14(3). htps://doi.org/0.1088/1758-5090/ac63ee
[5] Liao, Y.C. et al. (2024) Effects of the oxoaporphine alkaloid hernandonine on dengue virus. Evidence for its mechanisms of action. Phytomedicine 155986. https://doi.org/10.1016/j.phymed.2024.155986