Posted by The low aqueous solubility of fat-soluble vitamis (vitamins A, D, E, and K) often necessitates the use of pharmaceutical excipients to benefit from their medicinal efficiency. A successful example of this is the formation of the inclusion complexes with cyclodextrins (CDs) to accomplish diverse objectives, with CDs predominantly employed as solubilizers and absorption enhancers. This article examines studies detailing the synthesis and the biological, physicochemical, and structural characteristics of the inclusion complexes formed between fat-soluble vitamins and different cyclodextrins. This thorough review with 170 references demonstrates that although the fat-soluble vitamins form stable complexes with various CDs, the kind of CDs employed significantly influences the resultant properties of the complex formed.
Zielińska-Pisklak, M.; Michalik, K.A.; Szeleszczuk, Ł. Complexes of Fat-Soluble Vitamins with Cyclodextrins. Int. J. Mol. Sci. 2025, 26, 6110. https://doi.org/10.3390/ijms26136110
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