Posted by Oral drug administration has become the most common and preferred mode of disease treatment due to its good medication adherence and convenience. For orally administered drugs, the safety, efficacy, and targeting ability requirements have grown as disease treatment research advances. It is difficult to obtain prominent efficacy of traditional drugs simply via oral administration. Numerous studies have demonstrated that cyclodextrins (CDs) can improve the clinical applications of certain orally administered drugs by enhancing their water solubility and masking undesirable odors. Additionally, deeper studies have discovered that CDs can influence disease treatment by altering the drug pharmacokinetics (PK) or pharmacodynamics (PD). This review highlights recent research progress on the PK and PD effects of CD-based oral drug delivery in disease therapy.
PK/PD alterations of CD-based oral drug delivery formulations are discussed for
- Anti-infective drugs,
- Antihypertensive drug,
- Antiepileptic drugs
- Anti-tumor drugs/immunosuppressants
- Antihyperglycemic drug
- NSAIDs/glucocorticoids
- Other drugs.
Several examples are listed in large Tables.
Hui Liu, Songlin Guo, Shijie Wei, Jiayue Liu, Bingren Tian (2024) Pharmacokinetics and pharmacodynamics of cyclodextrin-based oral drug delivery formulations for disease therapy. Carbohydrate Polymers 329,
121763. https://doi.org/10.1016/j.carbpol.2023.121763.