Posted by This research aims to create the nanofibers (NF) which involves incorporating an antiviral agent, oseltamivir (OTV) into the CD cavity, forming inclusion complexes (IC) that greatly improve drug encapsulation efficiency.
Utilizing methyl beta-CD (MCD) as effective host molecules, IC can be created with OTV molecules that are soluble in water. This results in an enhancement of the biological activity of the OTV. The formed IC can be efficiently incorporated into NF through electrospinning, leading to NFs with rapid dissolution properties. To serve as a suitable matrix for these NFs, PVA is chosen due to its non-toxicity and water solubility.
To assess the physicochemical properties and drug-loading capabilities of these CD-based NF, a variety of characterization techniques can be utilized. It is noteworthy that NF containing OTV:MCD-IC/PVA demonstrates a continuous release of OTV (89.25%) at acidic conditions (pH 5.8) when compared to NF holding no MCD materials.
The biocompatibility assessments indicate that these treatments do not trigger apoptosis in fibroblast cells, implying a favorable safety profile regarding the induction of programmed cell death in these cells.
Rajaram Rajamohan, Kuppusamy Murugavel, Alia Almoajel, Mohamed Farouk Elsadek, Sivakumar Allur Subramanian, Sung Jae Kim, Sanjeevram Dhandapani, Yong Rok Lee (2024) Fabrication of biocompatible water-soluble supramolecular nanofibers of oseltamivir with methyl-β-cyclodextrin for enhanced drug release. Journal of Drug Delivery Science and Technology 97, 105769.
https://doi.org/10.1016/j.jddst.2024.105769.