Posted by Anemia, especially iron deficiency anemia (IDA) is a global health problem that affects both adults and children, but treatment is hampered by serious side effects, primarily associated with the gastrointestinal tract with oral administration of drugs. There are various oral formulationsT on the market, but iron typically is released from them in the stomach. The aggressive digestive environment in the stomach frequently causes premature release, so designing a stimulus-sensitive delivery system for iron compounds for oral administration is relevant.
In this study, the authors aimed to develop an oral form of iron compounds using polymethylsilsesquioxane hydrogels. To boost loading efficiency and prolong release, the iron compounds (FeCl3 and ferrous D-Gluconate) are incorporated into a guest–host complex with 2-hydroxypropyl-beta-cyclodextrin. The optimal system underlines a combination of ferrous D-Gluconate and HPCD in a 1:1 molar ratio, embedded into a hydrogel with a modest quantity of silicate crosslinks. It was demonstrated that iron release in a gastric media was reduced.
Orlova, P.; Meshkov, I.; Latipov, E.; Vasiliev, S.; Mikheev, I.; Ratova, D.-M.; Kalinina, A.; Muzafarov, A.; Le-Deygen, I. Cyclodextrin—Polymethylsilsesquioxane Combined System as a Perspective Iron Delivery System for Oral Administration. Gels 2024, 10, 564. https://doi.org/10.3390/gels10090564