Posted by While being some of the oldest supramolecular hosts, cyclodextrins remain very popular as molecular binders in materials, devices, artificial enzymes and more. The popularity is undoubtedly connected to the ready availability, carbohydrate biomass origin, biodegradability and water solubility of the cyclodextrins. Many of these applications require synthetic modification of the cyclodextrin – at the simplest the attachment of a linker – but also often attachment of several functional groups, lids, bridges etc. The present work reviews the state of the art methods of modifying α-cyclodextrin, which include direct modications of unprotected α-cyclodextrin and protection/deprotection method to partially modified cyclodextrins.
Bilge Deniz Özcan, Morten Lang Zimmermann, Mingzhe Ren and Mikael Bols (2024) New methods of modification of α-cyclodextrin. Org. Biomol. Chem., https://doi.org/10.1039/D4OB01109K