Dual encapsulation and sequential release of cisplatin and vitamin E from soy polysaccharides and β-cyclodextrin bioadhesive hydrogel nanoparticles

This study applied pH-thermal dual responsive bio-adhesive chemically cross-linked hydrogel nanoparticles (HGNPs) for dual complexation and enhanced the controlled release and bioavailability of cisplatin (CDDP) and Vitamin E (VE) drugs. The CDDP was loaded into the HGNPs via chemical conjugation with the carboxyl groups in the HGNPs surface by soy polysaccharides (SSPS), while VE was complexed by the β-cyclodextrin (β-CD). The HGNPs showed a uniform HGNPs size distribution of 90.77 ± 14.77 nm and 81.425 ± 13.21 nm before and after complexation, respectively. The FTIR, XRD, XPS, and zeta potential confirmed the conjugation. The cumulative release percent of CDDP reached 98 % at pH 1.2, while <45 % was released at pH 7.4. The loading of CDDP and VE was 15 ± 0.33 and 11.32 ± 0.25 wt%, respectively. Moreover, the CDDP and VE also released slower from the HGNPs at 25 °C than at 37 °C and 42 °C. The (VE/CDDP)-loaded HGNPs exhibited longer circulation time in vivo than free CDDP and free VE suspension.

Mohamed Eid, Jingsong Zhu, Muhammad Asif Ismail, Bin Li (2024) Dual encapsulation and sequential release of cisplatin and vitamin E from soy polysaccharides and β-cyclodextrin bioadhesive hydrogel nanoparticles. International Journal of Biological Macromolecules 273, 133240,
https://doi.org/10.1016/j.ijbiomac.2024.133240.