Insight into the drug delivery efficacy and anti-diabetic potential of cyclodextrin against hyperglycemia

Based on 57 references this review gives a thorogh overview on CDs both as delivery systems for antidiabetic drugs and as active ingredients having antidiabetic effect. Different types of CDs and its derivatives have been used for preparing varieties of micro/nano-carriers to deliver diverse anti-diabetic molecules, including insulin, GLP-1, α-lipoic acid, bilirubin etc. to reduce hyperglycemia. Furthermore, numerous studies demonstrated the positive role of different types of CD in inhibiting the activities of carbohydrate digestive enzymes followed by delaying the starch digestion and thereby lowering the postprandial glycemic response. 

The review contains interesting statistics, such as: According to the latest global estimate by International Diabetes Federation (IDF) (Nov 2021), 537 million people (adults) are suffering from diabetes and the global prevalence is 10.5 % which means one in ten adults is being affected by the disease. The incidence has risen by 16 % (74 million) from the last IDF estimates, 2019. 

Survey found that 4 out of 5 adult diabetic patients belong to the low-and middle-income countries. India reports 2nd highest incidence of diabetes in the world after China (1st rank). 

Bhaben Sharmah, Joydeep Das, Prasenjit Manna (2024) Insight into the drug delivery efficacy and anti-diabetic potential of cyclodextrin against hyperglycemia. Inorganic Chemistry Communications 161, 112034. https://doi.org/10.1016/j.inoche.2024.112034.