A prestigious award for studies of INACTIVE pharmaceutical ingredients (Ralph Shangraw Memorial Award)

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University of Mississippi pharmacy professor, Michael Repka has been announced as recipient of the 2023 Ralph Shangraw Memorial Award. Professor Repka earns the Shangraw award for his study of inactive pharmaceutical ingredients, including cyclodextrins (CDs). This recognition by the International Pharmaceutical Excipients Council of the Americas Foundation is an acknowledgement of Repka’s efforts in the field of pharmaceutical excipients, or inactive medicinal ingredients.
This award recognizes research achievements broadly in the field of pharmaceutical excipients, including but not limited to, research that contributes to:
• an understanding of the basic science underlying excipient functionality,
• excipient safety, including the development of test methods and standards,
• the development of new excipients or novel use of existing excipients in new applications, and
• the development of rational compendial/regulatory standards for excipients.


The 2023 award was presented to prof. Repka during the AAPS Annual Meeting, which took place between October 22-25 in Orlando, Florida. Congratulations Professor Repka!
For the readers of CD-News it may be of interest to mention that Professor Repka’s research work covered in part also the utility of excipient CDs in different pharmaceutical dosage forms. (For illustration of Repka’s works with CDs, we mention References.1-4)
Who is Ralph Shangraw?
The award is named for Ralph F. Shangraw, a professor who spent nearly 40 years teaching and studying excipients at the University of Maryland School of Pharmacy, in Baltimore and devoting many years of service to the expert committees of the U.S. Pharmacopeia. He was also a founding member of the American Association of Pharmaceutical Scientists. Among many excipients, Dr. Shangraw worked also in the application of CDs and CD derivatives as excipients. The first communication by Shangraw’s team on CDs as tableting excipients, was published in 1988. They compared the compactibility of beta-CD with that of Avicel and Fast Flo lactose, and reported that beta-CD had superior compactability and so can be useful in direct compression. (5)
Some of us may remember, that Professor Shangraw delivered a seminal lecture at the 5th International CD Symposium in Paris, in 1990, on the tableting properties of parent beta-CD and discussed the processing variables on inclusion complex formation. In his talk he also emphasized the importance of residual water content in the excipient performance of crystalline CD, pointing on the optimal, 14% residual water content in crystalline CD. (6)

References

  1. C. Reddy Palem , S. Kumar Battu, R. Gannu, V. V. Yamsani, M. A Repka, M. Rao Yamsani Role of cyclodextrin complexation in felodipine-sustained release matrix tablets intended for oral transmucosal delivery: in vitro and ex vivo characterization Pharm. Dev. Technol. 2012 May-Jun;17(3):321-32. doi: 10.3109/10837450.2010.535829. Epub 2011 Jan 26.
  2. S. B. Upadhye, S. J. Kulkarni, S. Majumdar, M.A. Avery, W.G. Mahmoud A. ElSohly, and M. A. Repka Preparation and Characterization of Inclusion Complexes of a Hemisuccinate Ester Prodrug of Δ9-Tetrahydrocannabinol with Modified Beta-Cyclodextrins
    AAPS PharmSciTech. 2010 Jun; 11(2): 509–517.
  3. D. Real, D. Leonardi, R. O. Williams, M. A. Repka, and C. J. Salomon: Solving the Delivery Problems of Triclabendazole Using Cyclodextrins AAPS PharmSciTech (# 2018) DOI: 10.1208/s12249-018-1057-5
  4. V. K. Shankar , A. Police , P. P., Z. G Cuny, M. A. Repka, R.J. Doerksen, S. N..Murthy
    Optimization of sulfobutyl-ether-β-cyclodextrin levels in oral formulations to enhance progesterone bioavailability Int. J. Pharm. 2021 Mar 1:596:120212.
    doi: 10.1016/j.ijpharm.2021.120212. Epub 2021 Jan 23.
  5. Gala, P. B.; Shangraw, R.F. Characterization of cyclodextrins and their tableting properties Pharm. Res. 5(10), Suppl. S232, 1988.
    The physical and tableting properties of beta-CD were studied. Parameters measured included particle size, density, moisture content, equilibrium moisture content, thermal analysis,
  6. Shangraw, R. F.; Pande, G.; Gala, P. Characterization of the tableting properties of beta-cyclodextrin and the effects of processing variables on inclusion complex formation, compactibility and dissolution Minutes Int. Symp. Cyclodextrins, 5th, 547-58. Edited by: Duchene, Dominique. Ed. Sante: Paris, Fr., 1990.

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