Posted by One of the most widely used applications of cyclodextrins relates to their utilization as chiral selectors. They have several chiral centres, with five in every glucose unit. The chemical modifications of hydroxyl groups of cyclodextrins (i.e., acyl, alkyl, hydroxyalkyl, carboxyalkyl, suphoalkyl, and phosphate, etc.) provide further chiral recognition properties with their interactions. The chiral recognition properties of a cyclodextrin depend on the size, geometry, and chemical characters of its cavity. Chemically modified cyclodextrins have flexible structures, enabling enantioseparations via an induced fit. Several chiral centres, various interaction abilities, and the induced fit of derivatized cyclodextrins demonstrate the chiral recognitions across a broad spectrum of enantiomers.
The majority of chiral separations have been used with cyclodextrin selectors in gas chromatography and capillary electrophoresis. The cyclodextrins have also been frequently used for chiral separation in HPLC, SFC, and membrane separations.
This Special Issue provides a comprehensive updated overview on the usefulness of cyclodextrins as chiral selectors.
For further reading, please follow the link to the Special Issue website at: