Pentachloronitrobenzene (PCNB) is an organochlorine protective fungicide with poor water solubility. In this research, pentachloronitrobenzene/hydroxypropyl-β-cyclodextrin inclusion complex nanofibers (PCNB/HPβCD-IC-NF) with a stoichiometric ratio of 1:1 were prepared by polymer-free electrospinning for the establishment of a rapidly dissolving water-based drug delivery system. It was proved that the formation of PCNB/HPβCD-IC enhanced the water solubility and thermal stability of PCNB by phase solubility study and thermogravimetric analysis respectively. Specifically, the solubility of PCNB in 10 mM HPβCD solution enhanced about 2.83 times, while the initial thermal decomposition temperature of PCNB in PCNB/HPβCD-IC-NF was also increased from 124 °C to 235 °C. The antifungal activity experiment exhibited that the antifungal activity of PCNB/HPβCD-IC-NF against Rhizoctonia solani was 2.13 times higher than that of pure PCNB.
Shuang Gao, Lei Zong, Yuhang Zhang, Yang Zhang, Xinyu Guo, Guanhua Guo, Lixia Zhao, Fei Ye, Ying Fu,
Antifungal pentachloronitrobenzene/hydroxypropyl-beta-cyclodextrin inclusion complex nanofibers by electrospun with no polymer: Fabrication and characterization, Journal of Cleaner Production 413, 2023,