A new cyclodextrin-based antidote?

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Jelly fish poisoning, overdose of neuromuscular blockades and anticoagulants.

What do they have in common?

Cyclodextrins can work as antidotes in all cases.

This current article describes a new CD derivative as a potential UNIVERSAL reversal agent for anticoagulants.

OKL-1111 concentration-dependently reversed the in vitro anticoagulant effects of dabigatran, rivaroxaban, apixaban and edoxaban in the thrombin generation assay. Not to mention, that OKL-1111 also reversed the anticoagulant effect of the vitamin K antagonist warfarin, the low molecular weight heparin enoxaparin, the pentasaccharide fondaparinux and the platelet inhibitor clopidogrel in vivo.

But what is this magical molecule?

It is a modified gamma-cyclodextrin substituted at the 6th position with 6-mercaptohexanoic acid. Seems familiar? Maybe, but it is also unique in its way.

Check out the details here:


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