Nobel Prize for click chemistry

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Three chemists who pioneered ‘click chemistry,’ a technique for efficiently joining molecules together, have won this year’s Nobel Prize in Chemistry. Barry Sharpless and Morten Meldal laid the foundation for click chemistry and independently discovered a pivotal reaction that could be used to link two molecules — an azide and an alkyne — with relative ease. This is the second Nobel prize for Sharpless, who won a chemistry Nobel in 2001 for developing chiral catalysts. Carolyn Bertozzi used click chemistry to map living cells without disturbing their function. To do this, she developed new types of click reaction that do not require copper catalysis, called ‘bioorthogonal’ reactions.

Carolyn Bertozzi, Morten Meldal and Barry Sharpless (left to right) developed ways of joining molecules quickly and without unwanted by-products.Credit: James Tensuan/The New York Times/Redux/eyevine, University of Copenhagen, K.C. Alfred/San Diego Union-Tribune via ZUMA/Alamy

Click chemistry became an every day tool for cyclodextrin derivatization. In Scopus database there was 508 hits for the keywords of “cyclodextrin AND click” this morining (06.10.2022). Some reviews worth to read:

Synthesis of Functionalized b-Cyclodextrins by “Click Chemistry.”
Mori, T., Inoue, Y., Liu, Y., Ke, C., Yang, C., Yang, Z., & Wu, W. HETEROCYCLES, 2008, 76(1), 155. 

When Cyclodextrins Meet Click Chemistry
Pierre-Antoine Faugeras, Benjamin Boëns, Pierre-Henri Elchinger, François Brouillette, Daniel Montplaisir, Rachida Zerrouki, Romain Lucas, European Journal of organic Chemistry 2012, 4087-4105.

Fast, and All-or-none Click Reaction on Cyclodextrin and Amylose.
Yamamura, H., Shimohara, K., Kurata, R., Fujita, Y., Murata, K., Hayashi, T., & Miyagawa, A. Chemistry Letters, 2013, 42(6), 643–645. 

Click Reaction in Carbohydrate Chemistry: Recent Developments and Future Perspective
Kushwaha, D., Dwivedi, P., K. Kuanar, S., & K. Tiwari, V. Current Organic Synthesis, 2013, 10(1), 90–135. 

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