This study reports the development of rapidly dissolving cyclodextrin (CD)-based inclusion complex (IC) nanofibers by waterborne electrospinning for fast oral delivery of piroxicam. Scanning electron microscopy analysis revealed the formation of bead-free fibers with a mean diameter range of 170–500 nm at various concentrations of piroxicam; increasing the piroxicam loading decreased the fiber diameter. The formation of IC was demonstrated by X-ray diffraction (XRD) analysis by the disappearance of crystalline peaks of piroxicam. Likewise, differential scanning calorimetry (DSC) analysis showed the disappearance of the melting peak of the embedded piroxicam due to IC formation. Both Fourier transform infrared (FTIR) and thermogravimetric analysis (TGA) confirmed the presence of piroxicam within the fibers. 1H NMR experiments demonstrated Px preservation in the fibers after six months. Piroxicam-loaded nanofibers were employed for sublingual drug delivery. To mimic the environment of the mouth, the nanofibers were treated with artificial saliva, which revealed the instant dissolution of the nanofibers. Furthermore, dissolution experiments were performed on the tissues wetted with artificial saliva, where the dissolution of the fibers could be extended to a few seconds, demonstrating the suitability of the materials for sublingual oral drug delivery. Overall, this paper, for the first time, reports the rapid oral delivery of piroxicam from polymer-free CD fibers produced by waterborne electrospinning without the requirement of any carrier polymer and toxic solvent.
Topuz F (2022) Rapid Sublingual Delivery of Piroxicam from Electrospun Cyclodextrin Inclusion Complex Nanofibers. ACS Omega, Publication Date:September 19, 2022