Novel Case Study with Sugammadex in Pregnant Women

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The use of sugammadex (SGM) after caesarean section is nowadays common practice, but there haven’t been reported any case studies in pregnant women undergoing non-obstetric surgery, except three cases but the possible effects on the fetus was unknown/not followed [1-3].

A case study report [4] of six pregnant women submitted to general anaesthesia for non-obstetric surgery in which neuromuscular blockade (NMB) rocuronium was reversed with sugammadex was reported.

In the study, no adverse events during general anaesthesia or in the immediate postoperative period were
reported; all fetuses showed good vitality in the cardiotocogram performed after the procedure; and all babies are healthy, without congenital abnormalities.

The conclusion is that all in these six cases of urgent non-obstetric surgery during pregnancy, sugammadex seemed to be a safe option for reversal of rocuronium-induced NMB for both mother and baby.

1. Martínez JCG, Sequera O, Guánchez G. Pheochromocytoma in pregnancy: a case report. J Anesth Crit Care Open Access. 2017;7:00266

2. Singh V, Bhakta P, Hashmi J, et al. Cardioversion in late pregnancy: a case report. Acta Anaesthesiol Belg. 2014;65:105—7.

3. Munro A, McKeen D, Coolen J. Maternal respiratory distress and successful reversal with sugammadex during intrauterine transfusion with fetal paralysis. Int J Obstet Anesth. 2019;39:129—31.

4. Sara Martins Torres, Duarte Filipe Duartea, Amélia Sousa Glória, Cláudia Reis, Joana Filipa Moreira, Sara Cunha, Lino Lopes Gomes, Caroline Dahlem, Sugammadex administration in pregnant patients undergoing non-obstetric surgery: a case series Braz J Anesthesiol, vol.72, n4, p.525-528, 2022

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