Encapsulation of menthol into cyclodextrin metal-organic frameworks

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Cyclodextrin (CD)-metal-organic frameworks (MOFs) are developed as a new type of food-acceptable multi-porous material, which shows a great potential for controlled volatile compound release. This study aimed to synthesize CD-MOFs from potassium nitrate, crystallized with α-CD, β-CD or γ-CD, and their complex capacities were further evaluated using menthol encapsulation. Compared with CD, all the CD-MOFs had highly ordered crystal structures and more regular shapes. β-CD-MOF showed better thermal stability, with an initial thermal degradation temperature of 253 °C, higher than the other two CD-MOFs. The CD-MOFs were used for menthol encapsulation and the resulting menthol concentration within the inclusion complexes (ICs) was determined. The menthol concentration in ICs followed the order: β-CD-MOF > β-CD > γ-CD-MOF > γ-CD > α-CD ≥ α-CD-MOF. The menthol content and encapsulation efficiency of β-CD-MOF were 21.76% (w/w) and 22.54% (w/w) respectively, significantly higher than those of other reported solid materials, such as amylose, CD and V-type starch.

The coordination environment of K+ ions with α-CD (a), β-CD (d) or γ-CD (g). Three-dimensional structures of α-CD-MOF (b and c), β-CD-MOF (e and f) and γ-CD-MOF (h and i) viewed along different co-ordinate axes.

Ziman Hu, Songnan Li, Shaokang Wang, Bin Zhang, Qiang Huang (2021) Encapsulation of menthol into cyclodextrin metal-organic frameworks: Preparation, structure characterization and evaluation of complexing capacity, Food Chemistry, 338,127839, https://doi.org/10.1016/j.foodchem.2020.127839.


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