Clinical trial: Nasal and Salivary Detection of the SARS-CoV-2 Virus After Antiviral Mouthrinses

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Given the current lack of effective COVID-19 treatment, it is necessary to explore alternative methods to contain the spread of the infection, focusing in particular on its mode of transmission. The modes of person-to-person transmission of SARS-CoV-2 are direct transmission, such as sneezing, coughing, transmission through inhalation of small droplets, and transmission through contact, such as contact with nasal, oral and eye mucous membranes. SARS-CoV-2 can also be transmitted directly or indirectly through saliva. The use of antiviral mouthrinses may be used as adjunctive therapy. The clinical trial aims at testing saliva and nasal mucosa for SARS-CoV-2 after application of mouthrinse containing beta-cyclodextrin and Citrox  [1, 2].

Cyclodextrin-containing mouthrinse is recommended for prevention of Covid-19 infection [3].

Citrox is a bioflavonoid preparation of antimicrobial effect against oral bacteria and Candida species [4], an ingredient of several mouthwash and toothcream formulations.

 

[1] ClinicalTrials.gov  NCT04352959. https://clinicaltrials.gov/ct2/show/NCT04352959

[2]J Carrouel, F., Conte, M.P., Fisher, J., Souza Gonçalves, L., Dussart, C., Llodra, J.C., Bourgeois, D. (2020) COVID-19: A Recommendation to Examine the Effect of Mouthrinses with β-Cyclodextrin Combined with Citrox in Preventing Infection and Progression. Clin Med 9(4), 1126. doi: 10.3390/jcm9041126.

[3] https://cyclodextrinnews.com/2020/04/29/like-soap-for-the-patients-mouth-cyclodextrins-are-important-for-future-of-oral-care/

[4] Hooper, S., Lewis, M., Wilson, M. et al. (2011) Antimicrobial activity of Citrox® bioflavonoid preparations against oral microorganisms. Br Dent J 210, E22 10.1038/sj.bdj.2010.1224

 

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