HPβ-CD as affordable antiviral to treat coronavirus infection
In a recent study posted to the bioRxiv* preprint server, researchers identified β-cyclodextrins (β-CDs) as a safe and cost-effective drug
Tag: SARS-CoV-2
Molecular docking assisted exploration on solubilization of poorly soluble drug remdesivir in sulfobutyl ether-beta-cyclodextrin: stabilization of supersaturated solution by changing pH from 1.7 to 3.5
In terms of solubilization effect, it was found that phase solubility of RDV increased significantly from intrinsic 1.7 mmol/L at
Impact of Remdesivir on SARS-CoV-2 Clearance in a Real-Life Setting: A Matched-Cohort Study
There were 648 patients enrolled in the study (216 cases and 432 controls). Viral clearance (VC) was observed in 490
HPBCD inhibits SARS-CoV-2 replication and virus-induced inflammatory cytokines
COVID-19 is marked by extensive damage to the respiratory system, often accompanied by systemic manifestations, due to both viral cytopathic
Buccal administration of remdesivir – still far from reality
As remdesivir, the first FDA-approved drug for SARS-CoV-2 infection, can be used only for hospitalized patients due to intravenous administration,
Use of Antivirals in SARS-CoV-2 Infection. Critical Review of the Role of Remdesivir
The aim of this report is to review the literature and shed light on the uncertainties surrounding the use of
Scientists are racing to develop more COVID antivirals
Nature News evaluated antiviral drugs developed for the treatment of Covid-19. Clinical-trial data showed that molnupiravir, developed by the pharmaceutical
Alpha-cyclodextrin and Hydroxytyrosol against SARS-CoV-2 infection
In the last year, the Cyclodextrin News reported on an oral spray containing alpha-cyclodextrin and hydroxytyrosol developed by Italian researchers
Memorial Sloan Kettering Cancer Center: Potential treatment of COVID-19 using inhalable camostat/nafamostat formulated with HPBCD or SBECD
Memorial Sloan Kettering Cancer Center (MSKCC) has filed a patent application on an inhalational therapeutic composition of camostat solubilized by
Harvard scientists discover the prophylactic effect of SBECD solubilized amodiaquine against SARS-CoV2 infection
Amodiaquine is a commonly used medicament for the treatment of malarial infections. It is a 4-aminoquinoline compound similar to chloroquine