Virus-Mediated Self-Assembly of Functional Cyclodextrins for Antiviral Inhibition
The autors report on a virus-mediated supramolecular assembly as an adaptive inhibitor of viral infection. Building on cyclodextrin (CD) host-guest
Tag: SARS-CoV-2
Hydroxypropyl-Beta-Cyclodextrin (HPBCD) inhibits SARS-CoV-2 replication by modulating intracellular lipid dynamics
A multi-year scientific collaboration between Brasilian and American scientists from Federal University at Rio de Janeiro, Brazil, Laboratory of Immunoregulation,
2,6‑di‑O‑methyl‑3‑acetyl‑β‑cyclodextrin: a novel approach to reducde infectivity of SARS‑CoV‑2 and Japanese encephalitis virus
Among 19 CD derivatives studied, pretreatment of viral particles with DMA-β-CyD significantly reduced infectivity (by 2.25–2.67 log₁₀ units after 180
Hydroxypropyl-Beta Cyclodextrin Barrier Prevents Respiratory Viral Infections
The emergence and mutation of pathogenic viruses have been occurring at an unprecedented rate in recent decades. The coronavirus disease
HPβ-CD as affordable antiviral to treat coronavirus infection
In a recent study posted to the bioRxiv* preprint server, researchers identified β-cyclodextrins (β-CDs) as a safe and cost-effective drug
Molecular docking assisted exploration on solubilization of poorly soluble drug remdesivir in sulfobutyl ether-beta-cyclodextrin: stabilization of supersaturated solution by changing pH from 1.7 to 3.5
In terms of solubilization effect, it was found that phase solubility of RDV increased significantly from intrinsic 1.7 mmol/L at
Impact of Remdesivir on SARS-CoV-2 Clearance in a Real-Life Setting: A Matched-Cohort Study
There were 648 patients enrolled in the study (216 cases and 432 controls). Viral clearance (VC) was observed in 490
HPBCD inhibits SARS-CoV-2 replication and virus-induced inflammatory cytokines
COVID-19 is marked by extensive damage to the respiratory system, often accompanied by systemic manifestations, due to both viral cytopathic
Buccal administration of remdesivir – still far from reality
As remdesivir, the first FDA-approved drug for SARS-CoV-2 infection, can be used only for hospitalized patients due to intravenous administration,
Use of Antivirals in SARS-CoV-2 Infection. Critical Review of the Role of Remdesivir
The aim of this report is to review the literature and shed light on the uncertainties surrounding the use of