History of Cyclodextrin Nanosponges

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In the series of historical reviews recently published
(https://cyclodextrinnews.com/2020/05/25/the-contribution-of-franz-schardinger-to-cyclodextrins/ and https://cyclodextrinnews.com/2020/05/27/the-history-of-sulfobutylether-beta-cyclodextrin/) also this historical overview on nanosponges deserves attention.

Cyclodextrin-based nanosponges (CD NSs) have recently emerged due to the outstanding properties attributable to their peculiar structure. In fact, alongside the common polysaccharide features, such as the presence of tunable functional groups and their ability to interact with biological tissues, what makes CD NSs unique is their three-dimensional network made up of crosslinked cyclodextrin units. The name “nanosponge” appeared for the first time in the 1990s due to their nanoporous, sponge-like structure and responded to the need to overcome the limitations of native cyclodextrins (CDs), particularly their water solubility and inability to encapsulate charged and large molecules efficiently. The origin and historical development of both water-soluble and swelling nanosponges over the last 50 years are reviewed under the following subtitles:

From the 1960s to the 1980s: Origin of Insoluble Crosslinked Cyclodextrin Polymers

From the 1980s to the 1990s: Investigation on Polymer Properties and Applications

1999:“In the Beginning Was the Word”

From 2000 to 2009: New Millennium Came with New Applications

From 2010 to 2015: Focus on Nanosponges as Delivery Systems

From 2016 to Present: State-of-the-Art and Future Prospects of Nanosponges

Read more:
Krabicová, I., Appleton, S.L., Tannous, M., Hoti, G., Pedrazzo, A.R., cecone, C., Cavalli, R., Trotta, F. 2020 History of cyclodextrin nanosponges. Polymers 12(5), 1122. https://www.mdpi.com/2073-4360/12/5/1122

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