Posted by The Table below was published in e-book
International Pulmonologist’s Consensus On Covid-19 2nd ed 2020
on April 22nd 2020 (ed. Tinku Joseph).
Table 11:
Summary of currently available drugs which can be potentially used for treatment of COVID-19
Disclaimer: The options listed below are not licensed for the treatment of COVID-19
| Agent | Classification | Mechanism of action | Dosage | Side effects |
| Hydroxychloroquine | Off label use | Hampers low pH dependent steps of viral replication | 400 mg BID x 2 doses, then 200 mg BID for 5days | QT prolongation |
| Oseltamivir | No trials on COVID-19 | Neuraminidase enzyme inhibitor in influenza | 75mg BID for 5 days | GI intolerance Headache Insomnia |
| Remdesivir | Investigational (can be used only on compassionate basis) | RNA dependent RNA polymerase inhibitor | 200 mg IV loading dose, then 100mgIV daily, up to 10 days | GI intolerance Hepatotoxicity |
| Lopinavir/ Ritonavir |
Off label use | 3CLpro (viral protease) inhibitor | 400/100 mg BID for up to 10 days | QT prolongation Hepatotoxicity |
| Interferon Beta B1 | Off label use | Immunomodulatory; enhancement of innate and adaptive viral immunity | Flu like syndrome depression | |
| Tocilizumab | Off label use | Monoclonal antibody to IL6 receptor / treats cytokine release syndrome | 4-8 mg/kg (max 400mg) IV and can be repeated up to three times 8 hours apart | Elevation of liver enzymes Increased risk of re-activation of other respiratory infections |
| Antibiotics (Broad spectrum) |
Initiate as per institution based | Secondary bacterial infection (CAP)/VAP | ||
| Corticosteroids | Not indicated in treating SARS CoV2 as per available evidence. Might prolong viral shedding.
Use as per indicated in refractory shock/macrophage activation syndrome/if patient has other indications for steroid use |
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| Convalescent Plasma with neutralizing antibody | Off label use | Antibodies from convalescent plasma might suppress viraemia. Theoretically: Better to start at early stage of disease | Consider IVIG at standard dose of 1 gm/kg daily x 2 doses | Might interact with antivirals |