Curcumin extract stabilized by gamma-CD

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Dr. Wolz Zell GmbH (Geisenheim, Germany) sells capsules containing curcumin (15%) and gamma-cyclodextrin as dietary supplement. The molecular encapsulation of curcumin results in 40-fold increase in bioavailability compared to pure curcumin due to enhanced solubility and stability.

Curcumin is a yellow chemical produced by some plants. The main source is turmeric (Curcuma longa), a member of ginger family. It is the ingredient of the well known spice blend: curry powder.

Curcumin is a diarylheptanoid, a tautomeric compound existing in enolic form in organic solvents and in keto form in water:

It has low aqueous solubility, chemical instability and low bioavailability.

Curcumin has been used historically in Ayurvedic medicine. It is claimed to have antiinflammatory effect, positive impact on blood pressure and blood cholesterol.

The gamma-CD complex of curcumin (produced by Wacker Chemie under the tradename of Cavacurmin) proved to provide 40-times enhanced blood concentration of curcumin compared with standard curcumin and commercial curcumin products after intake by 12 volunteers. Similar results were obtained in rodent model (Sprague Dawley rats) and in vitro test in Caco-2 cells.




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