Lessons from space studies on stability of a drug / cyclodextrin composition
Assessing the stability of drugs in space is crucial for future missions due to various environmental factors such as radiation,
Tag: remdesivir
Dual function of sulfobutylether-betadex in antiviral Veklury®: a remdesivir solubilizer and an effector
A recent publication written by a team of University of Debrecen reported that the excipient, sulfobutylether-betadex (SBECD), in Veklury® (remdesivir
Repetitive stability study of Remdesivir/Cyclodextrin complex on ISS
A preprint of a manuscript dealing with lessons learnt from a space project involving the stability study of remdesivir/cyclodextrin complex
Veklury® (remdesivir) formulations inhibit initial membrane-coupled events of SARS-CoV-2 infection due to their sulfobutylether-β-cyclodextrin content
Background and purpose: Despite its contradictory clinical performance, Veklury® (remdesivir) has a pivotal role in COVID-19 therapy. Possible contributions of the
Case Report: Severe SARS-CoV-2 Infection Treated with Remdesivir in a Patient with ESRD
Remdesivir has emerged as a promising antiviral drug against SARS-CoV-2. However, data regarding the clinical benefits of remdesivir in patients
Remdesivir- Dexolve formulation in the space – a book of NASA
In the annual report of NASA there is a great recognition of benefits of cyclodextrin technology even in space chemistry.
Molecular docking assisted exploration on solubilization of poorly soluble drug remdesivir in sulfobutyl ether-beta-cyclodextrin: stabilization of supersaturated solution by changing pH from 1.7 to 3.5
In terms of solubilization effect, it was found that phase solubility of RDV increased significantly from intrinsic 1.7 mmol/L at
Impact of Remdesivir on SARS-CoV-2 Clearance in a Real-Life Setting: A Matched-Cohort Study
There were 648 patients enrolled in the study (216 cases and 432 controls). Viral clearance (VC) was observed in 490
Molecular docking assisted exploration on solubilization of poorly soluble drug remdesivir in sulfobutyl ether-beta-cyclodextrin
In terms of solubilization effect, it was found that phase solubility of RDV increased significantly from intrinsic 1.7 mmol/L at
Buccal administration of remdesivir – still far from reality
As remdesivir, the first FDA-approved drug for SARS-CoV-2 infection, can be used only for hospitalized patients due to intravenous administration,