The revival of cyclodextrins as active pharmaceutical ingredients
Discovered in 1891, cyclodextrins, derived from starchy food, have found many applications in the cosmetic, agriculture, food and pharmaceutical industries
Tag: Parkinson disease
A new therapeutic approach to neurodegeneration? An old, known drug restarts flow of brain-cleaning fluids
On 15 August, 2024 Douglas Kelley, professor of mechanical engineering at the University of Rochester and his co-workers published that
Towards Understanding Neurodegenerative Diseases: Insights from Caenorhabditis elegans
The elevated occurrence of debilitating neurodegenerative disorders, such as amyotrophic lateral sclerosis (ALS), Huntington’s disease (HD), Alzheimer’s disease (AD), Parkinson’s
Alpha-synuclein misfolding inhibitor minzasolmin dissolved in SBECD for treatment of Parkinson disease
Direct targeting of alpha-synuclein (ASYN) has emerged as a disease-modifying strategy for Parkinson’s disease and other synucleinopathies which is being
Molecular Mind Games: The Medicinal Action of Cyclodextrins in Neurodegenerative Diseases
This work presents the most recent advances in the research and clinical use of HPβCD against Niemann–Pick disease, a congenital
Minzasolmin in SBECD solution for synuclein targeting in Parkinson disease treatment
Direct targeting of alpha-synuclein (ASYN) has emerged as a disease-modifying strategy for Parkinson’s disease and other synucleinopathies which is being
The review article ‘Molecular Mind Games’ describes the latest developments in cyclodextrin research for the treatment of brain disorders
The human brain is a complex and intricate network of cells and molecules that control every aspect of our behaviour
Parkinson’s Disease Phenotypes in Patient Neuronal Cultures and Brain Organoids Improved by 2-Hydroxypropyl-β-Cyclodextrin Treatment
Parkinson-disease-patient-derived cells presented differences in their energetic profile, imbalanced proliferation, apoptosis, mitophagy, and a reduced differentiation efficiency to tyrosine hydroxylase
Nanotherapeutic and Stem Cell Therapeutic Strategies in Neurodegenerative Diseases: A Promising Therapeutic Approach
Neurodegeneration is characterized by progressive, disabling, and incurable neurological disorders with the massive loss of specific neurons. As one of
Cyclodextrins: Only Pharmaceutical Excipients or Full-Fledged Drug Candidates?
In this review, based on 250 references, the general chemical principles of direct cyclodextrin–protein interactions are summarized and highlighted, through