Sickle cell anemia and cyclodextrins
(The very first report on the beneficial consequence of cyclodextrin-assisted cholesterol removal from red blood cell membranes.) Sickle cell anemia
Tag: inflammation
Cyclodextrin attenuates atherosclerosis by diminishing gasdermin D (GSDMD)-mediated pyroptosis
Atherosclerosis is a progressive inflammatory disease characterized by the accumulation of lipids in the arterial vessel wall, which begins in
HPBCD and SBEBCD as therapeutic agents for the treatment of ulcerative collitis
Ulcerative colitis (UC), a major subtype of inflammatory bowel disease (IBD) alongside Crohn’s disease, is characterized by a relapsing and
Gut microbiota-dependent increase in phenylacetic acid induces endothelial cell senescence during aging
With advanced age, alterations of specific gut-derived metabolites such as aromatic amino acid derivatives might contribute to CVD through prolonged
Cellular senescence induced by cholesterol accumulation is mediated by lysosomal ABCA1 in APOE4 and AD
The association between cellular senescence and ABCA1 expression in human postmortem brain samples was studied using transcriptomic, histological, and biochemical
Alzheimer’s Disease as Type 3 Diabetes: Understanding the Link and Implications
Alzheimer’s disease (AD) and type 2 diabetes mellitus (T2DM) are two prevalent conditions that present considerable public health issue in
Nanomedicine-based drug delivery strategies for the treatment of atherosclerosis
This review provides a comprehensive overview of emerging nanomedicine-based strategies for targeted delivery of anti-atherosclerosis drugs, elucidating their distinct mechanisms
Resveratrol-βCD inhibited premature ovarian insufficiency progression by regulating granulosa cell autophagy
The ovarian environment of premature ovarian insufficiency (POI) patients exhibits immune dysregulation, which leads to excessive secretion of numerous proinflammatory
Oral alpha-cyclodextrin reverses cholesterol-crystal-induced retinal pathology in a rodent model of type 2 diabetes (T2D)
Dyslipidemia is common in individuals with T2D and clinical studies show cholesterol and lipid management reduce diabetic retinopathy (DR) progression.
Biomimetic nanoparticles to enhance the reverse cholesterol transport for selectively inhibiting development into foam cell in atherosclerosis
A disorder of cholesterol homeostasis is one of the main initiating factors in the progression of atherosclerosis (AS). Metabolism and