Impact of cholesterol homeostasis within cochlear cells on auditory development and hearing loss
Cholesterol is the most abundant sterol molecule in mammalian cells, which not only constitutes the cell membrane but also plays
Tag: hearing loss
Different solubilizing ability of cyclodextrin derivatives for cholesterol in Niemann–Pick disease type C treatment
Cyclodextrins (CDs), the therapeutic candidates for Niemann–Pick disease type C (NPC), function dually as a shuttle and sink that catalytically
Time- and frequency-dependent changes in acoustic startle reflex amplitude following cyclodextrin-induced outer and inner cell loss
The acoustic startle reflex (ASR) amplitude can be enhanced or suppressed by noise-induced hearing loss or age-related hearing loss; however,
Cochlear spiral ganglion neuron degeneration following cyclodextrin-induced hearing loss
HPβCD as a treatment for Niemann-Pick Type C1 disease can reduce some debilitating symptoms and extend life span, but the
Hydroxypropyl-β-cyclodextrin causes massive damage to the developing auditory and vestibular system
2-hydroxypropyl-β-cyclodextrin (HPβCD), a cholesterol chelator used to treat Niemann-Pick C1 (NPC1) lysosomal storage disease, causes hearing loss in mammals by