Cyclodextrin-assisted drug delivery to Central Nervous System: Mavenclad™ for multiple sclerosis treatment
In a recent study, Professors Bodor and Buchwald review the use of cyclodextrin-enabled formulations to develop oral tablets of cladribine
Tag: Blood-brain barrier
Grafting of Cyclodextrin to Theranostic Nanoparticles Improves Blood-Brain Barrier Model Crossing
Core–shell superparamagnetic iron oxide nanoparticles hold great promise as a theranostic platform in biological systems. Herein, we report the biological
Computational Modeling on Binding Interactions of Cyclodextrins with the Human Multidrug Resistance P-glycoprotein
Molecular docking approaches and DFT ab initio simulations were combined for the first time, to study the key interactions of
Nasal powders of quercetin-β-cyclodextrin derivatives complexes with mannitol/lecithin microparticles for Nose-to-Brain delivery: In vitro and ex vivo evaluation
Quercetin, a flavonoid with possible neuroprotective action has been recently suggested for the early-stage treatment of Alzheimer’s disease. The low
Delivering Crocetin across the Blood-Brain Barrier by Using γ-Cyclodextrin to Treat Alzheimer’s Disease
Scientific report has published a paper on γ-cyclodextrin-enabled crocetin formulation which can deliver crocetin into the brain. [1] Crocetin (CRT)
Book: Advances and Avenues in the Development of Novel Carriers for Bioactives and Biological Agents
Advances and Avenues in the Development of Novel Carriers for Bioactives and Biological Agents provides sound data on the utility of
Therapeutic potential for cyclodextrin‐based macromolecular systems in NPC
A paper has just come out in Macromolecular Rapid Communications highlighting the potential benefits of cyclodextrin-based macromolecular systems as cholesterol-mopping
HPBCD can cross the Brain-Blood Barrier
Matencio et al. reported in their recent paper that 92.8% of HPBCD administered intrathecally to a child suffering from Niemann